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Sec24d Gene Detail
Summary
  • Symbol
    Sec24d
  • Name
    SEC24 homolog D, COPII coat complex component
  • Synonyms
    2310020L09Rik, LOC383951
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916858
    NCBI Gene: 69608
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:123061104-123159290 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 53.82 cM, cytoband G3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3580 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916858
 protein coding gene Chr3:123058451-123159290 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027848
 protein coding gene Chr3:125579321-125678111 (+)
A/J MGP_AJ_G0027807
 protein coding gene Chr3:121364958-121465445 (+)
AKR/J MGP_AKRJ_G0027772
 protein coding gene Chr3:124466093-124566910 (+)
BALB/cJ MGP_BALBcJ_G0027819
 protein coding gene Chr3:121179309-121277488 (+)
C3H/HeJ MGP_C3HHeJ_G0027549
 protein coding gene Chr3:124863235-124963684 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028264
 protein coding gene Chr3:130117383-130219437 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025601
 protein coding gene Chr3:116786433-116888322 (+)
CAST/EiJ MGP_CASTEiJ_G0027004
 protein coding gene Chr3:124274307-124377613 (+)
CBA/J MGP_CBAJ_G0027524
 protein coding gene Chr3:134513041-134624279 (+)
DBA/2J MGP_DBA2J_G0027665
 protein coding gene Chr3:120494287-120592440 (+)
FVB/NJ MGP_FVBNJ_G0027633
 protein coding gene Chr3:118117389-118218453 (+)
LP/J MGP_LPJ_G0027775
 protein coding gene Chr3:127100775-127201981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027663
 protein coding gene Chr3:142088439-142205175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028320
 protein coding gene Chr3:124023163-124133372 (+)
PWK/PhJ MGP_PWKPhJ_G0026730
 protein coding gene Chr3:120241389-120342432 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026554
 protein coding gene Chr3:122129130-122234080 (+)
WSB/EiJ MGP_WSBEiJ_G0027084
 protein coding gene Chr3:124769415-124877650 (+)



Homology
more
  • Human Ortholog
    SEC24D, SEC24 homolog D, COPII component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC24D, SEC24 homolog D, COPII component
  • Synonyms
    CLCRP2
  • Links
    NCBI Gene ID: 9871
    UniProt: O94855

  • Chr Location
    4q26; chr4:118722822-118838683 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEC24D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality. A hypomorphic gene trap allele results in lethality during organogenesis.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    7
  • cDNA Data
    71
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039234 Ensembl Gene Model | MGI Sequence Detail 98187 C57BL/6J ±  kb
    transcript ENSMUST00000047923 Ensembl | MGI Sequence Detail 3903 Not Applicable  
    polypeptide ENSMUSP00000035823 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR029006 ADF-H/Gelsolin-like domain superfamily
      IPR007123 Gelsolin-like domain
      IPR036180 Gelsolin-like domain superfamily
      IPR012990 Sec23/Sec24 beta-sandwich
      IPR050550 SEC23/SEC24 family, SEC24 subfamily
      IPR006900 Sec23/Sec24, helical domain
      IPR036175 Sec23/Sec24 helical domain superfamily
      IPR006896 Sec23/Sec24, trunk domain
      IPR041742 Sec24-like, trunk domain
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR006895 Zinc finger, Sec23/Sec24-type
    • GlyGen
      Q6NXL1 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2686195
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 6
      Diseases 1
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/16/2026
    MGI 6.24     		The Jackson Laboratory