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Vkorc1l1 Gene Detail
Summary
  • Symbol
    Vkorc1l1
  • Name
    vitamin K epoxide reductase complex, subunit 1-like 1
  • Synonyms
    2310024K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916818
    NCBI Gene: 69568
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:129970950-130015533 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 68.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    934 from dbSNP Build 142
  • Strain Annotations
    28
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916818
 protein coding gene Chr5:129970811-130015533 (+)
129S1/SvImJ ENSMUSG00200052423
 protein coding gene Chr15:80414714-80415921 (-)
129S1/SvImJ ENSMUSG00200043335
 protein coding gene Chr5:123716356-123761088 (+)
A/J ENSMUSG00195049857
 protein coding gene Chr15:80340999-80342206 (-)
A/J ENSMUSG00195048553
 protein coding gene Chr5:123250591-123295313 (+)
AKR/J ENSMUSG00220049320
 protein coding gene Chr5:122727028-122771753 (+)
BALB/cJ ENSMUSG00180037814
 protein coding gene Chr5:123357950-123402667 (+)
BALB/cJ ENSMUSG00180052885
 protein coding gene Chr15:80217930-80219137 (-)
C3H/HeJ ENSMUSG00175048754
 protein coding gene Chr15:80528863-80530070 (-)
C3H/HeJ ENSMUSG00175034524
 protein coding gene Chr5:125326646-125371366 (+)
C57BL/6NJ ENSMUSG00215052174
 protein coding gene Chr15:80306837-80308044 (-)
C57BL/6NJ ENSMUSG00215048588
 protein coding gene Chr5:123388755-123433481 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027792
 protein coding gene Chr5:122775495-122820403 (+)
CAST/EiJ ENSTCUG00005009228
 protein coding gene Chr5:122622927-122667442 (+)
CBA/J ENSMUSG00210047710
 protein coding gene Chr15:80303849-80305056 (-)
CBA/J ENSMUSG00210007274
 protein coding gene Chr5:124077318-124122040 (+)
DBA/2J ENSMUSG00185050780
 protein coding gene Chr15:80337323-80338530 (-)
DBA/2J ENSMUSG00185007402
 protein coding gene Chr5:127129270-127173998 (+)
FVB/NJ ENSMUSG00205042481
 protein coding gene Chr5:123010489-123055207 (+)
JF1/MsJ ENSUMUG00000042270
 protein coding gene Chr5:130019174-130063579 (+)
LP/J ENSMUSG00230039831
 protein coding gene Chr15:83655064-83656271 (-)
LP/J ENSMUSG00230042984
 protein coding gene Chr5:131232268-131276992 (+)
NOD/ShiLtJ ENSMUSG00190039185
 protein coding gene Chr5:123032201-123076947 (+)
NOD/ShiLtJ ENSMUSG00190043688
 protein coding gene Chr15:80320982-80322189 (-)
NZO/HlLtJ ENSMUSG00225012926
 protein coding gene Chr5:138927699-138972422 (+)
PWK/PhJ ENSLUMG00010017701
 protein coding gene Chr5:121902507-121946992 (+)
SPRET/EiJ ENSMSPG00010029224
 protein coding gene Chr5:125321224-125371479 (+)
WSB/EiJ ENSIUOG00005029295
 protein coding gene Chr5:125711207-125755958 (+)



Homology
more
  • Human Ortholog
    VKORC1L1, vitamin K epoxide reductase complex subunit 1L1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VKORC1L1, vitamin K epoxide reductase complex subunit 1L1
  • Links
    NCBI Gene ID: 154807
    UniProt: Q8N0U8

  • Chr Location
    7q11.21; chr7:65865772-65959563 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal survival and hemostatic phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    5
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69568 NCBI Gene Model | MGI Sequence Detail 44584 C57BL/6J ±  kb
    transcript NM_027121 RefSeq | MGI Sequence Detail 4935 C57BL/6  
    polypeptide Q6TEK5 UniProt | EBI | MGI Sequence Detail 176 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory