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Antxr1 Gene Detail
Summary
  • Symbol
    Antxr1
  • Name
    anthrax toxin receptor 1
  • Synonyms
    2310008J16Rik, 2810405N18Rik, Tem8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916788
    NCBI Gene: 69538
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87110835-87312757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5681 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916788
 protein coding gene Chr6:87110835-87312803 (-)
129S1/SvImJ ENSMUSG00200042700
 protein coding gene Chr6:84075203-84278322 (-)
A/J ENSMUSG00195038787
 protein coding gene Chr6:83754258-83957427 (-)
AKR/J ENSMUSG00220032811
 protein coding gene Chr6:82672241-82866730 (-)
BALB/cJ ENSMUSG00180015304
 protein coding gene Chr6:84145437-84339926 (-)
C3H/HeJ ENSMUSG00175030338
 protein coding gene Chr6:93066917-93270042 (+)
C57BL/6NJ ENSMUSG00215024042
 protein coding gene Chr6:84136214-84339120 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028608
 protein coding gene Chr6:83235283-83450491 (-)
CAST/EiJ ENSTCUG00005016844
 protein coding gene Chr6:84079206-84277602 (-)
CBA/J ENSMUSG00210043128
 protein coding gene Chr6:83950385-84153506 (-)
DBA/2J ENSMUSG00185038255
 protein coding gene Chr6:84497507-84700634 (-)
FVB/NJ ENSMUSG00205023250
 protein coding gene Chr6:83123106-83326249 (-)
JF1/MsJ ENSUMUG00000018088
 protein coding gene Chr6:83445770-83641736 (-)
LP/J ENSMUSG00230045476
 protein coding gene Chr6:85631731-85834834 (-)
NOD/ShiLtJ ENSMUSG00190028393
 protein coding gene Chr6:83568854-83771967 (-)
NZO/HlLtJ ENSMUSG00225018622
 protein coding gene Chr6:87598477-87801566 (-)
PWK/PhJ ENSLUMG00010032999
 protein coding gene Chr6:82860441-83057299 (-)
SPRET/EiJ ENSMSPG00010038036
 protein coding gene Chr6:84994266-85190559 (-)
WSB/EiJ ENSIUOG00005031968
 protein coding gene Chr6:84489910-84684383 (-)



Homology
more
  • Human Ortholog
    ANTXR1, ANTXR cell adhesion molecule 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANTXR1, ANTXR cell adhesion molecule 1
  • Synonyms
    ATR, GAPO, TEM8
  • Links
    NCBI Gene ID: 84168
    UniProt: Q9H6X2

  • Chr Location
    2p13.3; chr2:69013144-69249327 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ANTXR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display female infertility and malocclusion of the incisors. Mice homozygous for a different knock-out allele exhibit malocclusion of incisors and increased extracellular matrix deposition in several organs, includingthe ovaries and uterus, but normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    28
  • cDNA Data
    9
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69538 NCBI Gene Model | MGI Sequence Detail 201923 C57BL/6J ±  kb
    transcript NM_054041 RefSeq | MGI Sequence Detail 5280 C57BL/6  
    polypeptide Q9CZ52 UniProt | EBI | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919432
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory