Lce3e Gene Detail

Summary

• Symbol
  Lce3e
• Name
  late cornified envelope 3E
• Synonyms
  2310001H18Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1916764
  NCBI Gene: 69514
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:92874368-92875588 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.14 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  249 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916764	protein coding gene	Chr3:92874368-92875588 (+)
129S1/SvImJ	ENSMUSG00200038911	protein coding gene	Chr3:89662045-89663265 (+)
A/J	ENSMUSG00195052851	protein coding gene	Chr3:89671405-89672625 (+)
AKR/J	ENSMUSG00220045129	protein coding gene	Chr3:88892553-88893773 (+)
BALB/cJ	ENSMUSG00180043415	protein coding gene	Chr3:89842373-89843593 (+)
C3H/HeJ	ENSMUSG00175042021	protein coding gene	Chr3:89609204-89610424 (+)
C57BL/6NJ	ENSMUSG00215047011	protein coding gene	Chr3:90220881-90222101 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025292	protein coding gene	Chr3:87157259-87157621 (+)
CAST/EiJ	ENSTCUG00005042505	protein coding gene	Chr3:89998911-90000131 (+)
CBA/J	ENSMUSG00210040799	protein coding gene	Chr3:89724293-89725513 (+)
DBA/2J	ENSMUSG00185046264	protein coding gene	Chr3:89942590-89943810 (+)
FVB/NJ	ENSMUSG00205048450	protein coding gene	Chr3:88718549-88719769 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230043796	protein coding gene	Chr3:91959497-91960717 (+)
NOD/ShiLtJ	ENSMUSG00190047063	protein coding gene	Chr3:90074391-90075611 (+)
NZO/HlLtJ	ENSMUSG00225009750	protein coding gene	Chr3:94807005-94808225 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010045294	protein coding gene	Chr3:90031301-90032525 (+)
WSB/EiJ	ENSIUOG00005048914	protein coding gene	Chr3:90226218-90227438 (+)

Homology

• Human Ortholog
  LCE3B, late cornified envelope 3B

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LCE3B, late cornified envelope 3B
  
• Synonyms
  LEP14
• Links
  HGNC:29462

  NCBI Gene ID: 353143

  UniProt: Q5TA77

  
  
• Chr Location
  1q21.3; chr1:152613811-152614098 (+)  GRCh38

---

• Human Ortholog
  LCE3C, late cornified envelope 3C
  
• Synonyms
  LEP15, SPRL3A
• Links
  HGNC:16612

  NCBI Gene ID: 353144

  UniProt: Q5T5A8

  
  
• Chr Location
  1q21.3; chr1:152600234-152601086 (+)  GRCh38

---

• MGI Vertebrate Homology
  Lce3e stringent orthology
  2 human;1 mouse;4 rat
  
• HCOP
  vertebrate homology predictions: LCE3B, LCE3C
• Gene Tree
  Lce3e
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving Lce3e
• Find Mice (IMSR)
  4 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  597
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS57229.1

• Ensembl
  ENSMUSG00000074433 (Evidence)
• NCBI Gene
  69514

Representative Sequences			Length	Strain/Species
genomic	69514	NCBI Gene Model | MGI Sequence Detail	1221	C57BL/6J
transcript	NM_001254725	RefSeq | MGI Sequence Detail	607	C57BL/6
polypeptide	NP_001241654	RefSeq | MGI Sequence Detail	98	C57BL/6

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR028205 Late cornified envelope protein

Molecular
Reagents

• All nucleic 2

  cDNA 2

  
  

  Microarray probesets 1

References

• Summaries
  All 21

  Diseases 1

  Gene Ontology 1

  Phenotypes 7
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lce3e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30316	Chr3:92874366-92874369 (+)	0 bp