Tmem127 MGI Mouse Gene Detail - MGI:1916720

Symbol

Tmem127
Name

transmembrane protein 127
Synonyms

2310003P10Rik

Feature Type

protein coding gene
IDs

MGI:1916720
NCBI Gene: 69470
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:127089868-127103028 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.87 cM
Mapping Data

3 experiments

SNPs within 2kb

103 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916720	protein coding gene	Chr2:127089828-127103028 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026454	protein coding gene	Chr2:130525154-130538379 (+)
A/J	MGP_AJ_G0026418	protein coding gene	Chr2:125231811-125245043 (+)
AKR/J	MGP_AKRJ_G0026393	protein coding gene	Chr2:128806898-128820123 (+)
BALB/cJ	MGP_BALBcJ_G0026430	protein coding gene	Chr2:125500967-125514164 (+)
C3H/HeJ	MGP_C3HHeJ_G0026173	protein coding gene	Chr2:129327744-129340910 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026875	protein coding gene	Chr2:134620798-134634687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024252	protein coding gene	Chr2:120075990-120088973 (+)
CAST/EiJ	MGP_CASTEiJ_G0025634	protein coding gene	Chr2:129535256-129548437 (+)
CBA/J	MGP_CBAJ_G0026153	protein coding gene	Chr2:139610184-139623350 (+)
DBA/2J	MGP_DBA2J_G0026287	protein coding gene	Chr2:124643178-124656344 (+)
FVB/NJ	MGP_FVBNJ_G0026251	protein coding gene	Chr2:123287909-123301135 (+)
LP/J	MGP_LPJ_G0026392	protein coding gene	Chr2:130758429-130773600 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026271	protein coding gene	Chr2:143641834-143655079 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026930	protein coding gene	Chr2:128838124-128851315 (+)
PWK/PhJ	MGP_PWKPhJ_G0025370	protein coding gene	Chr2:124187395-124200776 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025172	protein coding gene	Chr2:127911857-127926785 (+)
WSB/EiJ	MGP_WSBEiJ_G0025708	protein coding gene	Chr2:129731379-129744634 (+)

Human Ortholog

TMEM127, transmembrane protein 127

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM127, transmembrane protein 127
Links

HGNC:26038

NCBI Gene ID: 55654

neXtProt AC: NX_O75204

UniProt: O75204
Chr Location

2q11.2; chr2:96248514-96265997 (-) GRCh38

MGI Vertebrate Homology

Tmem127 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM127
Gene Tree

Tmem127

Diseases

1 with human TMEM127 associations

				Human Disease	Mouse Models
				pheochromocytoma IDs pheochromocytoma DOID:0050771 MESH:D010673 OMIM:171300

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

30 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Tmem127
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Lysosomal activity and endosomal fusion mediated by Rab5 were affected in mouse embryonic fibroblasts of homozygous null mutants

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

2
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem127

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All Sequences

52
RefSeq

4
UniProt

3
CCDS

CCDS16697.1, CCDS89551.1

Ensembl

ENSMUSG00000034850 (Evidence)
NCBI Gene

69470

			Length	Strain/Species	Flank
genomic	69470	NCBI Gene Model \| MGI Sequence Detail	13161	C57BL/6J	± kb
transcript	NM_175145	RefSeq \| MGI Sequence Detail	4772	ZRU/MplStud
polypeptide	Q8BGP5	UniProt \| EBI \| MGI Sequence Detail	238	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029797 transmembrane protein 127

(term hierarchy)
InterPro Domains

IPR033331 Transmembrane protein 127

IPR046795 Transmembrane protein 127, transmembrane region

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All nucleic 12

Genomic 1

cDNA 11

Microarray probesets 5

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MGI:2138878, MGI:2138898

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:340371 Guo Q, et al., TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation. Cell Rep. 2023 Sep 1;42(9):113070

TSS for Tmem127:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19998	Chr2:127089859-127089917 (+)	20 bp
Tssr19999	Chr2:127089918-127089957 (+)	70 bp
Tssr20000	Chr2:127089973-127089984 (+)	111 bp
Tssr20001	Chr2:127100529-127100547 (+)	10,670 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23