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Jsrp1 Gene Detail
Summary
  • Symbol
    Jsrp1
  • Name
    junctional sarcoplasmic reticulum protein 1
  • Synonyms
    2300003C06Rik, 2310032K21Rik, JP-45, JP45
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916700
    NCBI Gene: 71912
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80644330-80649332 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916700
 protein coding gene Chr10:80644330-80649359 (-)
129S1/SvImJ ENSMUSG00200044125
 protein coding gene Chr10:77270622-77274543 (-)
A/J ENSMUSG00195042051
 protein coding gene Chr10:77666192-77670113 (-)
AKR/J ENSMUSG00220047667
 protein coding gene Chr10:77263882-77267803 (-)
BALB/cJ ENSMUSG00180047330
 protein coding gene Chr10:77676665-77680586 (-)
C3H/HeJ ENSMUSG00175046922
 protein coding gene Chr10:77547411-77551332 (-)
C57BL/6NJ ENSMUSG00215052031
 protein coding gene Chr10:77289271-77293192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015604
 protein coding gene Chr10:74809387-74814657 (-)
CAST/EiJ ENSTCUG00005048192
 protein coding gene Chr10:77174774-77178707 (-)
CBA/J ENSMUSG00210045349
 protein coding gene Chr10:77403447-77407368 (-)
DBA/2J ENSMUSG00185050321
 protein coding gene Chr10:77745875-77749796 (-)
FVB/NJ ENSMUSG00205044953
 protein coding gene Chr10:77458677-77462598 (-)
JF1/MsJ ENSUMUG00000053213
 protein coding gene Chr10:78977223-78981142 (-)
LP/J ENSMUSG00230050063
 protein coding gene Chr10:79515509-79519430 (-)
NOD/ShiLtJ ENSMUSG00190049914
 protein coding gene Chr10:77659598-77663519 (-)
NZO/HlLtJ ENSMUSG00225050998
 protein coding gene Chr10:83802002-83805923 (-)
PWK/PhJ ENSLUMG00010038760
 protein coding gene Chr10:77337588-77341502 (-)
SPRET/EiJ ENSMSPG00010042649
 protein coding gene Chr10:78953604-78958734 (-)
WSB/EiJ ENSIUOG00005044752
 protein coding gene Chr10:77363342-77367251 (-)



Homology
more
  • Human Ortholog
    JSRP1, junctional sarcoplasmic reticulum protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JSRP1, junctional sarcoplasmic reticulum protein 1
  • Synonyms
    JP-45, JP45
  • Links
    NCBI Gene ID: 126306
    UniProt: Q96MG2

  • Chr Location
    19p13.3; chr19:2252074-2269759 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit muscle weakness, abnormal voluntary movement and abnormal muscle physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    9
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020216 Ensembl Gene Model | MGI Sequence Detail 5003 C57BL/6J ±  kb
    transcript ENSMUST00000181039 Ensembl | MGI Sequence Detail 1108 Not Applicable  
    polypeptide ENSMUSP00000137666 Ensembl | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009228 junctional sarcoplasmic reticulum protein 1
      (term hierarchy)
    • InterPro Domains
      IPR026178 Junctional sarcoplasmic reticulum protein 1
    • GlyGen
      Q3MI48 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1919162
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:235459 Mosca B, et al., Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles. J Biol Chem. 2016 Jul 8;291(28):14555-65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory