Fam110b MGI Mouse Gene Detail - MGI:1916593 - family with sequence similarity 110, member B

Symbol

Fam110b
Name

family with sequence similarity 110, member B
Synonyms

1700012H17Rik

Feature Type

protein coding gene
IDs

MGI:1916593
NCBI Gene: 242297
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:5644009-5801101 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 2.62 cM
Mapping Data

2 experiments

SNPs within 2kb

814 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916593	protein coding gene	Chr4:5644009-6108223 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028032	protein coding gene	Chr4:2169404-2644064 (+)
A/J	MGP_AJ_G0027990	protein coding gene	Chr4:2188228-2648609 (+)
AKR/J	MGP_AKRJ_G0027956	protein coding gene	Chr4:2166799-2637560 (+)
BALB/cJ	MGP_BALBcJ_G0028002	protein coding gene	Chr4:2148005-2615660 (+)
C3H/HeJ	MGP_C3HHeJ_G0027732	protein coding gene	Chr4:2293711-2760081 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028445	protein coding gene	Chr4:2336650-2839199 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025789	protein coding gene	Chr4:1952076-2383141 (+)
CAST/EiJ	MGP_CASTEiJ_G0027185	protein coding gene	Chr4:2197181-2648701 (+)
CBA/J	MGP_CBAJ_G0027707	protein coding gene	Chr4:2285460-2792253 (+)
DBA/2J	MGP_DBA2J_G0027847	protein coding gene	Chr4:2153728-2602065 (+)
FVB/NJ	MGP_FVBNJ_G0027814	protein coding gene	Chr4:2050330-2511629 (+)
LP/J	MGP_LPJ_G0027958	protein coding gene	Chr4:2217625-2686817 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027847	protein coding gene	Chr4:2555058-3060019 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028504	protein coding gene	Chr4:2152981-2604761 (+)
PWK/PhJ	MGP_PWKPhJ_G0026907	protein coding gene	Chr4:2187044-2646425 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026737	protein coding gene	Chr4:2123238-2587314 (+)
WSB/EiJ	MGP_WSBEiJ_G0027265	protein coding gene	Chr4:2280748-2738904 (+)

Human Ortholog

FAM110B, family with sequence similarity 110 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM110B, family with sequence similarity 110 member B
Synonyms

C8orf72
Links

HGNC:28587

NCBI Gene ID: 90362

neXtProt AC: NX_Q8TC76

UniProt: Q8TC76
Chr Location

8q12.1; chr8:57994444-58149718 (+) GRCh38.p7

Alliance of Genome Resources

Fam110b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM110B
Gene Tree

Fam110b

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

159
Endonuclease-mediated

1
Gene trapped

155
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

121 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FAM110B

Xenbase fam110b

ZFIN fam110b

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Fam110b interacts with 235 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

71
RefSeq

20
UniProt

2
CCDS

CCDS17948.1

Ensembl

ENSMUSG00000049119 (Evidence)
NCBI Gene

242297

			Length	Strain/Species	Flank
genomic	242297	NCBI Gene Model \| MGI Sequence Detail	157093	C57BL/6J	± kb
transcript	NM_173426	RefSeq \| MGI Sequence Detail	3257	C57BL/6
polypeptide	Q8C739	UniProt \| EBI \| MGI Sequence Detail	366	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030947 protein FAM110B

(term hierarchy)
InterPro Domains

IPR025741 Centrosome-associated, FAM110, C-terminal domain

IPR025739 Centrosome-associated, FAM110, N-terminal domain

IPR025740 FAM110

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:2140550

Summaries

All 33

Gene Ontology 2

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Fam110b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36378	Chr4:5644084-5644129 (+)	98 bp
Tssr36379	Chr4:5644133-5644211 (+)	163 bp
Tssr36380	Chr4:5644216-5644240 (+)	219 bp
Tssr36381	Chr4:5644268-5644279 (+)	265 bp
Tssr36382	Chr4:5724304-5724357 (+)	80,322 bp
Tssr36383	Chr4:5786673-5786675 (+)	142,665 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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