Ctdspl MGI Mouse Gene Detail - MGI:1916524 - CTD small phosphatase like

Symbol

Ctdspl
Name

CTD small phosphatase like
Synonyms

2810418J22Rik, HYA22, SCP3

Feature Type

protein coding gene
IDs

MGI:1916524
NCBI Gene: 69274
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:118755521-118873066 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 71.07 cM, cytoband F4
Mapping Data

3 experiments

SNPs within 2kb

695 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916524	protein coding gene	Chr9:118751313-118873187 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035408	protein coding gene	Chr9:121641135-121757952 (+)
A/J	MGP_AJ_G0035388	protein coding gene	Chr9:117143551-117261015 (+)
AKR/J	MGP_AKRJ_G0035321	protein coding gene	Chr9:120178101-120295368 (+)
BALB/cJ	MGP_BALBcJ_G0035384	protein coding gene	Chr9:117005221-117126188 (+)
C3H/HeJ	MGP_C3HHeJ_G0035092	protein coding gene	Chr9:120642856-120765700 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035907	protein coding gene	Chr9:124957817-125101365 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032790	protein coding gene	Chr9:114332894-114453100 (+)
CAST/EiJ	MGP_CASTEiJ_G0034396	protein coding gene	Chr9:120598988-120722374 (+)
CBA/J	MGP_CBAJ_G0035059	protein coding gene	Chr9:129665453-129801483 (+)
DBA/2J	MGP_DBA2J_G0035218	protein coding gene	Chr9:116577822-116696681 (+)
FVB/NJ	MGP_FVBNJ_G0035165	protein coding gene	Chr9:115419363-115538127 (+)
LP/J	MGP_LPJ_G0035297	protein coding gene	Chr9:121974850-122104661 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035206	protein coding gene	Chr9:130669378-130794789 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035926	protein coding gene	Chr9:120557378-120683189 (+)
PWK/PhJ	MGP_PWKPhJ_G0034103	protein coding gene	Chr9:116982123-117108122 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033937	protein coding gene	Chr9:120652793-120777009 (+)
WSB/EiJ	MGP_WSBEiJ_G0034517	protein coding gene	Chr9:120446743-120569303 (+)

Human Ortholog

CTDSPL, CTD small phosphatase like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTDSPL, CTD small phosphatase like
Synonyms

C3orf8, HYA22, PSR1, RBSP3, SCP3
Links

HGNC:16890

NCBI Gene ID: 10217

neXtProt AC: NX_O15194

UniProt: O15194
Chr Location

3p22.2; chr3:37861880-37984469 (+) GRCh38

MGI Vertebrate Homology

Ctdspl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CTDSPL
Gene Tree

Ctdspl

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

7
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Ctdspl
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

41
cDNA Data

88
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctdspl

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All Sequences

48
RefSeq

6
UniProt

2
CCDS

CCDS23605.1

Ensembl

ENSMUSG00000047409 (Evidence)
NCBI Gene

69274

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047409	Ensembl Gene Model \| MGI Sequence Detail	117546	C57BL/6J	± kb
transcript	ENSMUST00000073109	Ensembl \| MGI Sequence Detail	4589	Not Applicable
polypeptide	ENSMUSP00000072852	Ensembl \| MGI Sequence Detail	276	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006001 CTD small phosphatase-like protein

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR040078 CTD small RNA polymerase II polypeptide A phosphatase-like

IPR011948 Dullard phosphatase domain, eukaryotic

IPR004274 FCP1 homology domain

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

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All nucleic 88

cDNA 88

Microarray probesets 4

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MGI:2143037

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 18
Earliest

J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Ctdspl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87657	Chr9:118755566-118755636 (+)	80 bp
Tssr87658	Chr9:118755706-118755722 (+)	193 bp
Tssr3049	Chr9:118755731-118755742 (+)	216 bp
Tssr87659	Chr9:118776395-118776398 (+)	20,876 bp
Tssr87660	Chr9:118788806-118788810 (+)	33,287 bp
Tssr87661	Chr9:118864086-118864088 (+)	108,566 bp
Tssr87662	Chr9:118866729-118866731 (+)	111,209 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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