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Gins1 Gene Detail
Summary
  • Symbol
    Gins1
  • Name
    GINS complex subunit 1
  • Synonyms
    2810418N01Rik, Psf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916520
    NCBI Gene: 69270
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:150751482-150773200 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.75 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916520
protein coding gene Chr2:150747320-150773200 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026633
protein coding gene Chr2:155350981-155381232 (+)
A/J MGP_AJ_G0026600
protein coding gene Chr2:149105638-149132157 (+)
AKR/J MGP_AKRJ_G0026571
protein coding gene Chr2:153432880-153461214 (+)
BALB/cJ MGP_BALBcJ_G0026610
protein coding gene Chr2:149539060-149569293 (+)
C3H/HeJ MGP_C3HHeJ_G0026353
protein coding gene Chr2:153864350-153893793 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027058
protein coding gene Chr2:159896456-159923985 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024430
protein coding gene Chr2:142974734-143001464 (+)
CAST/EiJ MGP_CASTEiJ_G0025813
protein coding gene Chr2:154119385-154144903 (+)
CBA/J MGP_CBAJ_G0026332
protein coding gene Chr2:165751351-165785951 (+)
DBA/2J MGP_DBA2J_G0026466
protein coding gene Chr2:148352841-148378415 (+)
FVB/NJ MGP_FVBNJ_G0026431
protein coding gene Chr2:146809013-146834771 (+)
LP/J MGP_LPJ_G0026570
protein coding gene Chr2:155496255-155526562 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026453
protein coding gene Chr2:169858647-169891141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027113
protein coding gene Chr2:153364994-153394663 (+)
PWK/PhJ MGP_PWKPhJ_G0025548
protein coding gene Chr2:147979761-148006997 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025350
protein coding gene Chr2:152297060-152325637 (+)
WSB/EiJ MGP_WSBEiJ_G0025886
protein coding gene Chr2:154329998-154357684 (+)



Homology
more
  • Human Ortholog
    GINS1, GINS complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GINS1, GINS complex subunit 1
  • Synonyms
    IMD55, PSF1
  • Links
    NCBI Gene ID: 9837
    neXtProt AC: NX_Q14691
    UniProt: Q14691

  • Chr Location
    20p11.21; chr20:25391008-25452700 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human GINS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele display disorganized embryonic and extraembryonic structures and fail to develop past E5.5; mutant blastocysts fail to exhibit outgrowth in culture and show a cell proliferation defect and inner cell mass apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69270 NCBI Gene Model | MGI Sequence Detail 21719 C57BL/6J ±  kb
    transcript NM_027014 RefSeq | MGI Sequence Detail 1100 C57BL/6  
    polypeptide Q9CZ15 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 38
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory