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Hspb2 Gene Detail
Summary
  • Symbol
    Hspb2
  • Name
    heat shock protein family B (small) member 2
  • Synonyms
    27kDa, 2810021G24Rik, HSP27, MKBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916503
    NCBI Gene: 69253
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50662378-50663654 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916503
 protein coding gene Chr9:50662372-50663654 (-)
129S1/SvImJ ENSMUSG00200017947
 protein coding gene Chr9:47827093-47828362 (-)
A/J ENSMUSG00195019723
 protein coding gene Chr9:47516810-47518085 (-)
AKR/J ENSMUSG00220035218
 protein coding gene Chr9:47607514-47608790 (-)
BALB/cJ ENSMUSG00180029470
 protein coding gene Chr9:47628198-47629474 (-)
C3H/HeJ ENSMUSG00175014783
 protein coding gene Chr9:47640232-47641507 (-)
C57BL/6NJ ENSMUSG00215018356
 protein coding gene Chr9:47589814-47591090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032194
 protein coding gene Chr9:47599051-47600324 (-)
CAST/EiJ ENSTCUG00005014865
 protein coding gene Chr9:47547604-47548873 (-)
CBA/J ENSMUSG00210016417
 protein coding gene Chr9:47706111-47707385 (-)
DBA/2J ENSMUSG00185009625
 protein coding gene Chr9:47754682-47755957 (-)
FVB/NJ ENSMUSG00205033149
 protein coding gene Chr9:47981920-47983196 (-)
JF1/MsJ ENSUMUG00000031631
 protein coding gene Chr9:47803694-47804963 (-)
LP/J ENSMUSG00230040458
 protein coding gene Chr9:48042878-48044147 (-)
NOD/ShiLtJ ENSMUSG00190018051
 protein coding gene Chr9:47834772-47836046 (-)
NZO/HlLtJ ENSMUSG00225042835
 protein coding gene Chr9:48010529-48011804 (-)
PWK/PhJ ENSLUMG00010020179
 protein coding gene Chr9:47775161-47776437 (-)
SPRET/EiJ ENSMSPG00010010550
 protein coding gene Chr9:48583686-48584964 (-)
WSB/EiJ ENSIUOG00005017931
 protein coding gene Chr9:47249104-47250380 (-)



Homology
more
  • Human Ortholog
    HSPB2, heat shock protein family B (small) member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPB2, heat shock protein family B (small) member 2
  • Synonyms
    Hs.78846, HSP27, LOH11CR1K, MKBP
  • Links
    NCBI Gene ID: 3316
    UniProt: Q16082

  • Chr Location
    11q23.1; chr11:111912159-111914093 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the heart exhibit reduced state 3 mitochondrial respiration and ATP production following transverse aortic constriction despite normal cardiac hypertrophic response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    26
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038086 Ensembl Gene Model | MGI Sequence Detail 1277 C57BL/6J ±  kb
    transcript ENSMUST00000042790 Ensembl | MGI Sequence Detail 773 Not Applicable  
    polypeptide ENSMUSP00000042374 Ensembl | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 4
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 52
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:377042 Zou Y, et al., Heat shock protein 27 downregulation attenuates isoprenaline-induced myocardial fibrosis and diastolic dysfunction by modulating the endothelial-mesenchymal transition. Biochem Pharmacol. 2024 Dec;230(Pt 3):116612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory