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Tmem121 Gene Detail
Summary
  • Symbol
    Tmem121
  • Name
    transmembrane protein 121
  • Synonyms
    2410008J05Rik, Hole
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916445
    NCBI Gene: 69195
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113149550-113153143 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916445
 protein coding gene Chr12:113149523-113153143 (+)
129S1/SvImJ ENSMUSG00200026148
 protein coding gene Chr12:104934281-104937883 (+)
A/J ENSMUSG00195039791
 protein coding gene Chr12:107437326-107440912 (+)
AKR/J ENSMUSG00220035256
 protein coding gene Chr12:105367617-105371218 (+)
BALB/cJ ENSMUSG00180045947
 protein coding gene Chr12:106702961-106706564 (+)
C3H/HeJ ENSMUSG00175033621
 protein coding gene Chr12:109292418-109296003 (+)
C57BL/6NJ ENSMUSG00215045971
 protein coding gene Chr12:105970151-105973745 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018175
 protein coding gene Chr12:107637229-107640829 (+)
CAST/EiJ ENSTCUG00005036968
 protein coding gene Chr12:105445369-105448951 (+)
CBA/J ENSMUSG00210029728
 protein coding gene Chr12:106348856-106352442 (+)
DBA/2J ENSMUSG00185025701
 protein coding gene Chr12:108157187-108160775 (+)
FVB/NJ ENSMUSG00205031394
 protein coding gene Chr12:105369524-105373127 (+)
JF1/MsJ ENSUMUG00000012823
 protein coding gene Chr12:112927703-112931295 (+)
LP/J ENSMUSG00230042728
 protein coding gene Chr12:115198285-115201878 (+)
NOD/ShiLtJ ENSMUSG00190023699
 protein coding gene Chr12:104781260-104785702 (+)
NZO/HlLtJ ENSMUSG00225041822
 protein coding gene Chr12:116945783-116949385 (+)
PWK/PhJ ENSLUMG00010040591
 protein coding gene Chr12:106373315-106376911 (+)
SPRET/EiJ ENSMSPG00010016211
 protein coding gene Chr12:108656992-108658538 (+)
WSB/EiJ ENSIUOG00005036088
 protein coding gene Chr12:105354511-105358106 (+)



Homology
more
  • Human Ortholog
    TMEM121, transmembrane protein 121
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM121, transmembrane protein 121
  • Synonyms
    hhole, hole, TMEM121A
  • Links
    NCBI Gene ID: 80757
    UniProt: Q9BTD3

  • Chr Location
    14q32.33; chr14:105525996-105530205 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049036 Ensembl Gene Model | MGI Sequence Detail 3594 C57BL/6J ±  kb
transcript ENSMUST00000058491 Ensembl | MGI Sequence Detail 1574 Not Applicable  
polypeptide ENSMUSP00000055994 Ensembl | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory