About   Help   FAQ
Mcemp1 Gene Detail
Summary
  • Symbol
    Mcemp1
  • Name
    mast cell expressed membrane protein 1
  • Synonyms
    1810033B17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916439
    NCBI Gene: 69189
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3715754-3718916 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916439
 protein coding gene Chr8:3715754-3719259 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033314
 protein coding gene Chr8:611431-614097 (+)
A/J MGP_AJ_G0033297
 protein coding gene Chr8:582038-584667 (+)
AKR/J MGP_AKRJ_G0033228
 protein coding gene Chr8:611966-614595 (+)
BALB/cJ MGP_BALBcJ_G0033297
 protein coding gene Chr8:607800-610438 (+)
C3H/HeJ MGP_C3HHeJ_G0033011
 protein coding gene Chr8:625118-627747 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033807
 protein coding gene Chr8:658471-661614 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030780
 protein coding gene Chr8:533907-536573 (+)
CAST/EiJ MGP_CASTEiJ_G0032334
 protein coding gene Chr8:617087-620363 (+)
CBA/J MGP_CBAJ_G0032984
 protein coding gene Chr8:673498-676127 (+)
DBA/2J MGP_DBA2J_G0033138
 protein coding gene Chr8:552797-555426 (+)
FVB/NJ MGP_FVBNJ_G0033085
 protein coding gene Chr8:601676-604305 (+)
LP/J MGP_LPJ_G0033230
 protein coding gene Chr8:595618-598247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033120
 protein coding gene Chr8:651516-654145 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033825
 protein coding gene Chr8:602786-608054 (+)
PWK/PhJ MGP_PWKPhJ_G0032044
 protein coding gene Chr8:581395-584053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031888
 protein coding gene Chr8:594401-597147 (+)
WSB/EiJ MGP_WSBEiJ_G0032447
 protein coding gene Chr8:599176-603869 (+)



Homology
more
  • Human Ortholog
    MCEMP1, mast cell expressed membrane protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCEMP1, mast cell expressed membrane protein 1
  • Synonyms
    C19orf59
  • Links
    NCBI Gene ID: 199675
    neXtProt AC: NX_Q8IX19
    UniProt: Q8IX19

  • Chr Location
    19p13.2; chr19:7677088-7679829 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced mast cell proliferation and reduced airway inflammation in a chronic asthma model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69189 NCBI Gene Model | MGI Sequence Detail 3163 C57BL/6J ±  kb
transcript NM_026985 RefSeq | MGI Sequence Detail 1151 ZRU/MplStud  
polypeptide Q9D8U6 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:335318 Choi YJ, et al., Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nat Commun. 2023 Apr 11;14(1):2045
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory