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Alkbh3 Gene Detail
Summary
  • Symbol
    Alkbh3
  • Name
    alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
  • Synonyms
    1700108H04Rik, 1810020C19Rik, Abh3, mABH3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916363
    NCBI Gene: 69113
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:93810979-93841099 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.62 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    794 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916363
 protein coding gene Chr2:93810895-93841152 (-)
129S1/SvImJ ENSMUSG00200053145
 protein coding gene Chr2:90717244-90750008 (-)
A/J ENSMUSG00195051503
 protein coding gene Chr2:90852504-90885149 (-)
AKR/J ENSMUSG00220051208
 protein coding gene Chr2:90646480-90679144 (-)
BALB/cJ ENSMUSG00180054810
 protein coding gene Chr2:90752386-90785136 (-)
C3H/HeJ ENSMUSG00175052829
 protein coding gene Chr2:91010844-91043503 (-)
C57BL/6NJ ENSMUSG00215051036
 protein coding gene Chr2:90853271-90886031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023995
 protein coding gene Chr2:88097773-88128368 (-)
CAST/EiJ ENSTCUG00005052184
 protein coding gene Chr2:90275028-90305301 (-)
CBA/J ENSMUSG00210002064
 protein coding gene Chr2:91024747-91057507 (-)
DBA/2J ENSMUSG00185056694
 protein coding gene Chr2:90748673-90781418 (-)
FVB/NJ ENSMUSG00205048196
 protein coding gene Chr2:90032876-90065537 (-)
JF1/MsJ ENSUMUG00000008743
 protein coding gene Chr2:90582500-90614128 (-)
LP/J ENSMUSG00230000878
 protein coding gene Chr2:92499286-92532031 (-)
NOD/ShiLtJ ENSMUSG00190042377
 protein coding gene Chr2:90827271-90860016 (-)
NZO/HlLtJ ENSMUSG00225051632
 protein coding gene Chr2:100415193-100448338 (-)
PWK/PhJ ENSLUMG00010051533
 protein coding gene Chr2:90543740-90575371 (-)
SPRET/EiJ ENSMSPG00010008629
 protein coding gene Chr2:92528596-92565783 (-)
WSB/EiJ ENSIUOG00005053352
 protein coding gene Chr2:90547788-90580411 (-)



Homology
more
  • Human Ortholog
    ALKBH3, alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH3, alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  • Synonyms
    ABH3, DEPC-1, DEPC1, hABH3, PCA1
  • Links
    NCBI Gene ID: 221120
    UniProt: Q96Q83

  • Chr Location
    11p11.2; chr11:43880811-43920274 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    22 phenotype references
Mice homozygous for a knock-out allele exhibit a normal lifespan and are phenotypically indistinguishable from control littermates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    56
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69113 NCBI Gene Model | MGI Sequence Detail 30121 C57BL/6J ±  kb
transcript NM_001418696 RefSeq | MGI Sequence Detail 2238 C57BL/6  
polypeptide Q8K1E6 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    cDNA 56

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920823
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387162 Li Y, et al., ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid-beta Pathology. Adv Sci (Weinh). 2026 Mar 12;:e22572
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory