Atp2c2 MGI Mouse Gene Detail - MGI:1916297 - ATPase, Ca++ transporting, type 2C, member 2

Symbol

Atp2c2
Name

ATPase, Ca++ transporting, type 2C, member 2
Synonyms

1810010G06Rik

Feature Type

protein coding gene
IDs

MGI:1916297
NCBI Gene: 69047
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:120426748-120484456 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 68.21 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916297	protein coding gene	Chr8:120426748-120484457 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034191	protein coding gene	Chr8:123049431-123114459 (+)
A/J	MGP_AJ_G0034171	protein coding gene	Chr8:117974623-118033021 (+)
AKR/J	MGP_AKRJ_G0034098	protein coding gene	Chr8:121404785-121463967 (+)
BALB/cJ	MGP_BALBcJ_G0034165	protein coding gene	Chr8:118180582-118239075 (+)
C3H/HeJ	MGP_C3HHeJ_G0033876	protein coding gene	Chr8:122127683-122188769 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034685	protein coding gene	Chr8:127164011-127221894 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031627	protein coding gene	Chr8:110870696-110929278 (+)
CAST/EiJ	MGP_CASTEiJ_G0033203	protein coding gene	Chr8:122073219-122138444 (+)
CBA/J	MGP_CBAJ_G0033849	protein coding gene	Chr8:131793051-131854167 (+)
DBA/2J	MGP_DBA2J_G0034005	protein coding gene	Chr8:117195348-117254121 (+)
FVB/NJ	MGP_FVBNJ_G0033948	protein coding gene	Chr8:116231647-116293798 (+)
LP/J	MGP_LPJ_G0034094	protein coding gene	Chr8:123185502-123246583 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033995	protein coding gene	Chr8:134242959-134306213 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034703	protein coding gene	Chr8:121552076-121616010 (+)
PWK/PhJ	MGP_PWKPhJ_G0032905	protein coding gene	Chr8:116951971-117059218 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032745	protein coding gene	Chr8:120254730-120313810 (+)
WSB/EiJ	MGP_WSBEiJ_G0033319	protein coding gene	Chr8:122272491-122338331 (+)

Human Ortholog

ATP2C2, ATPase secretory pathway Ca2+ transporting 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP2C2, ATPase secretory pathway Ca2+ transporting 2
Synonyms

SPCA2
Links

HGNC:29103

NCBI Gene ID: 9914

neXtProt AC: NX_O75185

UniProt: O75185
Chr Location

16q24.1; chr16:84368527-84464187 (+) GRCh38

MGI Vertebrate Homology

Atp2c2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ATP2C2
Gene Tree

Atp2c2

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

32

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp2c2

less

All Sequences

41
RefSeq

4
UniProt

5
CCDS

CCDS52684.1

Ensembl

ENSMUSG00000034112 (Evidence)
NCBI Gene

69047

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034112	Ensembl Gene Model \| MGI Sequence Detail	57709	C57BL/6J	± kb
transcript	ENSMUST00000095171	Ensembl \| MGI Sequence Detail	3222	Not Applicable
polypeptide	ENSMUSP00000092794	Ensembl \| MGI Sequence Detail	944	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000004450 calcium-transporting ATPase type 2C member 2

(term hierarchy)
EC

7.2.2.10
InterPro Domains

IPR006068 Cation-transporting P-type ATPase, C-terminal

IPR004014 Cation-transporting P-type ATPase, N-terminal

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR018303 P-type ATPase, phosphorylation site

IPR006413 P-type ATPase, subfamily IIA, PMR1-type

IPR023298 P-type ATPase, transmembrane domain superfamily

less

All nucleic 32

cDNA 32

Microarray probesets 3

Summaries

All 35

Gene Ontology 10

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:325171 Fenech MA, et al., Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells. J Cell Physiol. 2016 Dec;231(12):2768-78

TSS for Atp2c2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79712	Chr8:120426756-120426801 (+)	31 bp
Tssr79713	Chr8:120480948-120480979 (+)	54,216 bp
Tssr79714	Chr8:120480981-120481005 (+)	54,245 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23