Zfas1 MGI Mouse Gene Detail - MGI:1916199 - zinc finger, NFX1-type containing 1, antisense RNA 1

Symbol

Zfas1
Name

zinc finger, NFX1-type containing 1, antisense RNA 1
Synonyms

1500012F01Rik, Zfos1

Feature Type

lncRNA gene
IDs

MGI:1916199
NCBI Gene: 68949
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:166904854-166907782 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 87.22 cM
Mapping Data

1 experiment

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916199	lncRNA gene	Chr2:166903619-166907799 (+)
129S1/SvImJ	ENSMUSG00200039948	protein coding gene	Chr2:163778024-163782517 (+)
129S1/SvImJ	ENSMUSG00200041591	lncRNA gene	Chr2:163779339-163782062 (+)
A/J	ENSMUSG00195025104	lncRNA gene	Chr2:164131628-164134557 (+)
A/J	ENSMUSG00195022928	protein coding gene	Chr2:164130225-164134831 (+)
AKR/J	ENSMUSG00220029928	protein coding gene	Chr2:163443732-163448338 (+)
AKR/J	ENSMUSG00220035630	lncRNA gene	Chr2:163445135-163448064 (+)
BALB/cJ	ENSMUSG00180037625	lncRNA gene	Chr2:163585278-163588206 (+)
BALB/cJ	ENSMUSG00180032842	protein coding gene	Chr2:163584211-163588480 (+)
C3H/HeJ	ENSMUSG00175045500	lncRNA gene	Chr2:164357207-164360136 (+)
C3H/HeJ	ENSMUSG00175040571	protein coding gene	Chr2:164355892-164360410 (+)
C57BL/6NJ	ENSMUSG00215028675	lncRNA gene	Chr2:163780037-163782966 (+)
C57BL/6NJ	ENSMUSG00215016327	protein coding gene	Chr2:163778634-163783240 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024702	protein coding gene	Chr2:158994733-158997752 (+)
CAST/EiJ	ENSTCUG00005009039	lncRNA gene	Chr2:162675898-162678622 (+)
CBA/J	ENSMUSG00210037286	protein coding gene	Chr2:164264589-164268859 (+)
CBA/J	ENSMUSG00210041903	lncRNA gene	Chr2:164265656-164268585 (+)
DBA/2J	ENSMUSG00185026373	lncRNA gene	Chr2:163985644-163988573 (+)
DBA/2J	ENSMUSG00185023911	protein coding gene	Chr2:163984577-163988847 (+)
FVB/NJ	ENSMUSG00205024099	protein coding gene	Chr2:163010934-163015452 (+)
FVB/NJ	ENSMUSG00205033207	lncRNA gene	Chr2:163012249-163015178 (+)
JF1/MsJ	ENSUMUG00000042246	lncRNA gene	Chr2:163624424-163627145 (+)
LP/J	ENSMUSG00230014078	lncRNA gene	Chr2:165540205-165542928 (+)
LP/J	ENSMUSG00230010223	protein coding gene	Chr2:165538890-165543383 (+)
NOD/ShiLtJ	ENSMUSG00190030310	protein coding gene	Chr2:163669263-163673781 (+)
NOD/ShiLtJ	ENSMUSG00190042662	lncRNA gene	Chr2:163670578-163673507 (+)
NZO/HlLtJ	ENSMUSG00225001548	protein coding gene	Chr2:173551490-173555760 (+)
NZO/HlLtJ	ENSMUSG00225003473	lncRNA gene	Chr2:173552557-173555486 (+)
PWK/PhJ	ENSLUMG00010039171	lncRNA gene	Chr2:163536084-163538805 (+)
SPRET/EiJ	ENSMSPG00010028871	lncRNA gene	Chr2:166285735-166288434 (+)
WSB/EiJ	ENSIUOG00005026460	lncRNA gene	Chr2:163373443-163376166 (+)

Human Ortholog

ZFAS1, ZNFX1 antisense RNA 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFAS1, ZNFX1 antisense RNA 1
Synonyms

C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1
Links

HGNC:33101

NCBI Gene ID: 441951
Chr Location

20q13.13; chr20:49277054-49299600 (+) GRCh38

MGI Vertebrate Homology

Zfas1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: ZFAS1
Gene Tree

Zfas1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

54
Endonuclease-mediated

2
Gene trapped

52
Incidental Mutations

APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

39

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

72
RefSeq

1
UniProt

1
CCDS

CCDS38338.1

Ensembl

ENSMUSG00000074578 (Evidence)
NCBI Gene

68949

			Length	Strain/Species	Flank
genomic	68949	NCBI Gene Model \| MGI Sequence Detail	2929	C57BL/6J	± kb
transcript	NR_138563	RefSeq \| MGI Sequence Detail	450	C57BL/6
polypeptide	Q3V494	UniProt \| EBI \| MGI Sequence Detail	79	Not Applicable

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UniProt

1 Sequence

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All nucleic 39

cDNA 39

Microarray probesets 3

Summaries

All 26

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:377389 Wu J, et al., Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis. Mol Cell Endocrinol. 2022 Jan 1;539:111490

TSS for Zfas1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21787	Chr2:166903190-166903209 (+)	-1,654 bp
Tssr21788	Chr2:166903211-166903222 (+)	-1,637 bp
Tssr21789	Chr2:166904735-166904774 (+)	-99 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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