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Clmb Gene Detail
Summary
  • Symbol
    Clmb
  • Name
    calcimembrin
  • Synonyms
    1190005I06Rik, Mict1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916168
    NCBI Gene: 68918
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121335341-121361129 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 69.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916168
 protein coding gene Chr8:121335341-121374371 (-)
129S1/SvImJ ENSMUSG00200040020
 protein coding gene Chr8:115676600-115702495 (-)
A/J ENSMUSG00195025218
 protein coding gene Chr8:115961679-115987582 (-)
AKR/J ENSMUSG00220039079
 protein coding gene Chr8:116151985-116177875 (-)
BALB/cJ ENSMUSG00180025325
 protein coding gene Chr8:116007501-116033395 (-)
C3H/HeJ ENSMUSG00175030378
 protein coding gene Chr8:116063886-116089780 (-)
C57BL/6NJ ENSMUSG00215020597
 protein coding gene Chr8:115637687-115663580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031638
 protein coding gene Chr8:111766294-111807845 (-)
CAST/EiJ ENSTCUG00005032584
 protein coding gene Chr8:115383528-115409411 (-)
CBA/J ENSMUSG00210035229
 protein coding gene Chr8:115991185-116017086 (-)
DBA/2J ENSMUSG00185034669
 protein coding gene Chr8:122095195-122121086 (-)
FVB/NJ ENSMUSG00205029556
 protein coding gene Chr8:114972168-114998077 (-)
JF1/MsJ ENSUMUG00000027435
 protein coding gene Chr8:124384786-124410627 (-)
LP/J ENSMUSG00230026483
 protein coding gene Chr8:125729865-125755754 (-)
NOD/ShiLtJ ENSMUSG00190018291
 protein coding gene Chr8:116105681-116131575 (-)
NZO/HlLtJ ENSMUSG00225042300
 protein coding gene Chr8:129095864-129121756 (-)
PWK/PhJ ENSLUMG00010036337
 protein coding gene Chr8:115806230-115832058 (-)
SPRET/EiJ ENSMSPG00010034921
 protein coding gene Chr8:118006456-118032503 (-)
WSB/EiJ ENSIUOG00005029019
 protein coding gene Chr8:116804834-116830859 (-)



Homology
more
  • Human Ortholog
    CLMB, calcimembrin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLMB, calcimembrin
  • Synonyms
    ASRA, C16orf74, MICT1
  • Links
    NCBI Gene ID: 404550
    UniProt: Q96GX8

  • Chr Location
    16q24.1; chr16:85690084-85751129 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice with conditional knock-out in brown adipose tissue show reduced thermogenic capacity, increased weight due to increased fat mass, and increased insulin resistance and impaired glucose tolerance when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    687
  • Tissues
    20
  • cDNA Data
    21
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68918 NCBI Gene Model | MGI Sequence Detail 25789 C57BL/6J ±  kb
    transcript NM_197988 RefSeq | MGI Sequence Detail 742 C57BL/6  
    polypeptide Q8K1L6 UniProt | EBI | MGI Sequence Detail 76 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR027864 Calcimembrin
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:8273622
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:374728 Dinh J, et al., The microprotein C16orf74/MICT1 promotes thermogenesis in brown adipose tissue. EMBO J. 2025 Jun;44(12):3381-3412
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory