About   Help   FAQ
Clmb Gene Detail
Summary
  • Symbol
    Clmb
  • Name
    calcimembrin
  • Synonyms
    1190005I06Rik, Mict1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916168
    NCBI Gene: 68918
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121335341-121361129 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 69.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916168
 protein coding gene Chr8:121335341-121374371 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034202
 protein coding gene Chr8:124043062-124087884 (-)
A/J MGP_AJ_G0034182
 protein coding gene Chr8:118892186-118932534 (-)
AKR/J MGP_AKRJ_G0034109
 protein coding gene Chr8:122346982-122394349 (-)
BALB/cJ MGP_BALBcJ_G0034176
 protein coding gene Chr8:119106783-119146616 (-)
C3H/HeJ MGP_C3HHeJ_G0033887
 protein coding gene Chr8:123086253-123128923 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034696
 protein coding gene Chr8:128168708-128213809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031638
 protein coding gene Chr8:111766294-111807845 (-)
CAST/EiJ MGP_CASTEiJ_G0033214
 protein coding gene Chr8:123080608-123123955 (-)
CBA/J MGP_CBAJ_G0033860
 protein coding gene Chr8:132853704-132901250 (-)
DBA/2J MGP_DBA2J_G0034016
 protein coding gene Chr8:118109769-118149535 (-)
FVB/NJ MGP_FVBNJ_G0033959
 protein coding gene Chr8:117182711-117223908 (-)
LP/J MGP_LPJ_G0034105
 protein coding gene Chr8:124161879-124206733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034006
 protein coding gene Chr8:135217961-135261571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034714
 protein coding gene Chr8:122520283-122563676 (-)
PWK/PhJ MGP_PWKPhJ_G0032916
 protein coding gene Chr8:117893030-117933767 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032756
 protein coding gene Chr8:121222621-121266569 (-)
WSB/EiJ MGP_WSBEiJ_G0033330
 protein coding gene Chr8:123255279-123301029 (-)



Homology
more
  • Human Ortholog
    CLMB, calcimembrin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLMB, calcimembrin
  • Synonyms
    ASRA, C16orf74, MICT1
  • Links
    NCBI Gene ID: 404550
    UniProt: Q96GX8

  • Chr Location
    16q24.1; chr16:85690084-85751129 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice with conditional knock-out in brown adipose tissue show reduced thermogenic capacity, increased weight due to increased fat mass, and increased insulin resistance and impaired glucose tolerance when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    20
  • cDNA Data
    21
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68918 NCBI Gene Model | MGI Sequence Detail 25789 C57BL/6J ±  kb
    transcript NM_197988 RefSeq | MGI Sequence Detail 742 C57BL/6  
    polypeptide Q8K1L6 UniProt | EBI | MGI Sequence Detail 111 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR027864 Protein of unknown function DUF4597
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:8273622
    References
    more
    • Summaries
      All 19
      Developmental Gene Expression 2
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:374728 Dinh J, et al., The microprotein C16orf74/MICT1 promotes thermogenesis in brown adipose tissue. EMBO J. 2025 Jun;44(12):3381-3412
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    01/20/2026
    MGI 6.24     		The Jackson Laboratory