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Fendrr Gene Detail
Summary
  • Symbol
    Fendrr
  • Name
    Foxf1 adjacent non-coding developmental regulatory RNA
  • Synonyms
    1110050K14Rik, linc-Foxf1a
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1916040
    NCBI Gene: 68790
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121781621-121809849 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916040
 lncRNA gene Chr8:121781621-121809849 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007390
 lincRNA gene Chr8:124528203-124558447 (-)
A/J MGP_AJ_G0007386
 lincRNA gene Chr8:119352658-119380767 (-)
AKR/J MGP_AKRJ_G0007358
 lincRNA gene Chr8:122835023-122864673 (-)
BALB/cJ MGP_BALBcJ_G0007364
 lincRNA gene Chr8:119568467-119596934 (-)
C3H/HeJ MGP_C3HHeJ_G0007308
 lincRNA gene Chr8:123564311-123595269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007535
 lincRNA gene Chr8:128667225-128698824 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006728
 lincRNA gene Chr8:112219952-112248290 (-)
CAST/EiJ MGP_CASTEiJ_G0007211
 lincRNA gene Chr8:123577608-123607764 (-)
CBA/J MGP_CBAJ_G0007290
 lincRNA gene Chr8:133390419-133426397 (-)
DBA/2J MGP_DBA2J_G0007313
 lincRNA gene Chr8:118560889-118589671 (-)
FVB/NJ MGP_FVBNJ_G0007334
 lincRNA gene Chr8:117649220-117677893 (-)
LP/J MGP_LPJ_G0007395
 lincRNA gene Chr8:124653275-124684490 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007311
 lincRNA gene Chr8:135703259-135736901 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007538
 lincRNA gene Chr8:123015326-123045978 (-)
PWK/PhJ MGP_PWKPhJ_G0007152
 lincRNA gene Chr8:118359324-118389008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007059
 lincRNA gene Chr8:121724827-121757013 (-)
WSB/EiJ MGP_WSBEiJ_G0007271
 lincRNA gene Chr8:123763580-123794706 (-)



Homology
more
  • Human Ortholog
    FENDRR, FOXF1 adjacent non-coding developmental regulatory RNA
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FENDRR, FOXF1 adjacent non-coding developmental regulatory RNA
  • Synonyms
    FOXF1AS1, FOXF1-AS1, lincFOXF1, onco-lncRNA-21, TCONS_00024240
  • Links
    NCBI Gene ID: 400550

  • Chr Location
    16q24.1; chr16:86474525-86509099 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die neonatally with respiratory failure and lung, gastrointestinal tract and heart defects. Homozygotes for another null allele show altered lung lobe development. Chimeric null embryos die during organogenesis with omphalocele and ventricle myocardium hypoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    36
  • cDNA Data
    4
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      28
    • RefSeq
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68790 NCBI Gene Model | MGI Sequence Detail 28229 C57BL/6J ±  kb
    transcript NR_130109 RefSeq | MGI Sequence Detail 2714 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 4
      Primer pair 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 16
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341586 Ali T, et al., Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element. Nucleic Acids Res. 2023 Jul 7;51(12):6227-6237
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory