Ppp4r3a MGI Mouse Gene Detail - MGI:1915984 - protein phosphatase 4 regulatory subunit 3A

Symbol

Ppp4r3a
Name

protein phosphatase 4 regulatory subunit 3A
Synonyms

1110034C04Rik, Smek1

Feature Type

protein coding gene
IDs

MGI:1915984
NCBI Gene: 68734
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:101005668-101049961 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.17 cM
Mapping Data

1 experiment

SNPs within 2kb

863 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915984	protein coding gene	Chr12:101005668-101051721 (-)
129S1/SvImJ	ENSMUSG00200023536	protein coding gene	Chr12:92774398-92818669 (-)
A/J	ENSMUSG00195017852	protein coding gene	Chr12:95335490-95379783 (-)
AKR/J	ENSMUSG00220035297	protein coding gene	Chr12:93242264-93286562 (-)
BALB/cJ	ENSMUSG00180030900	protein coding gene	Chr12:94492388-94536685 (-)
C3H/HeJ	ENSMUSG00175030164	protein coding gene	Chr12:97148433-97192723 (-)
C57BL/6NJ	ENSMUSG00215039621	protein coding gene	Chr12:93803763-93848049 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018028	protein coding gene	Chr12:95659084-95704099 (-)
CAST/EiJ	ENSTCUG00005017758	protein coding gene	Chr12:93444708-93488891 (-)
CBA/J	ENSMUSG00210013900	protein coding gene	Chr12:94151250-94195542 (-)
DBA/2J	ENSMUSG00185045732	protein coding gene	Chr12:95949335-95993597 (-)
FVB/NJ	ENSMUSG00205012983	protein coding gene	Chr12:93320976-93365262 (-)
JF1/MsJ	ENSUMUG00000016644	protein coding gene	Chr12:100658449-100702727 (-)
LP/J	ENSMUSG00230028838	protein coding gene	Chr12:103039473-103083741 (-)
NOD/ShiLtJ	ENSMUSG00190005190	protein coding gene	Chr12:91951493-91995789 (+)
NZO/HlLtJ	ENSMUSG00225037569	protein coding gene	Chr12:104763218-104807489 (-)
PWK/PhJ	ENSLUMG00010011970	protein coding gene	Chr12:94172327-94216572 (-)
SPRET/EiJ	ENSMSPG00010018762	protein coding gene	Chr12:96594266-96637735 (-)
WSB/EiJ	ENSIUOG00005008529	protein coding gene	Chr12:93158120-93202397 (-)

Human Ortholog

PPP4R3A, protein phosphatase 4 regulatory subunit 3A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP4R3A, protein phosphatase 4 regulatory subunit 3A
Synonyms

FLFL1, KIAA2010, MSTP033, PP4R3, PP4R3A, SMEK1, smk-1, smk1
Links

HGNC:20219

NCBI Gene ID: 55671

UniProt: Q6IN85
Chr Location

14q32.12; chr14:91457139-91510556 (-) GRCh38

MGI Vertebrate Homology

Ppp4r3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP4R3A
Gene Tree

Ppp4r3a

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

32
Targeted

3
Genomic Mutations

1 involving Ppp4r3a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available

Mice homozygous for a conditional allele exhibit increased anxiety- and depression-related behaviors with decreased miniature excitatory postsynaptic currents, decreased glutamate release, and decreased dendritic spine density.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

618
Tissues

12
cDNA Data

15
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp4r3a

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All Sequences

66
RefSeq

10
UniProt

4
CCDS

CCDS26111.1, CCDS49142.1

Ensembl

ENSMUSG00000041846 (Evidence)
NCBI Gene

68734

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041846	Ensembl Gene Model \| MGI Sequence Detail	44294	C57BL/6J	± kb
transcript	ENSMUST00000163095	Ensembl \| MGI Sequence Detail	4083	Not Applicable
polypeptide	ENSMUSP00000129654	Ensembl \| MGI Sequence Detail	833	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015281 serine/threonine-protein phosphatase 4 regulatory subunit 3A

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR011993 PH-like domain superfamily

IPR055236 PP4R3, EVH1-like domain

IPR051137 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like

IPR006887 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain
GlyGen

Q6P2K6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 17

Primer pair 1

Antibodies 2

Microarray probesets 7

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MGI:3037543

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:362264 Wei S, et al., SMEK1 ablation promotes glucose uptake and improves obesity-related metabolic dysfunction via AMPK signaling pathway. Am J Physiol Endocrinol Metab. 2024 Jun 1;326(6):E776-E790

TSS for Ppp4r3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117354	Chr12:101049912-101049976 (-)	17 bp
Tssr117353	Chr12:101049834-101049870 (-)	109 bp
Tssr117352	Chr12:101049708-101049746 (-)	234 bp
Tssr117351	Chr12:101039799-101039803 (-)	10,160 bp
Tssr117350	Chr12:101032669-101032673 (-)	17,290 bp
Tssr117349	Chr12:101024987-101024998 (-)	24,968 bp
Tssr117348	Chr12:101006388-101006392 (-)	43,571 bp
Tssr117347	Chr12:101006329-101006349 (-)	43,622 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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