Arb2a MGI Mouse Gene Detail - MGI:1915925 - ARB2 cotranscriptional regulator A

Symbol

Arb2a
Name

ARB2 cotranscriptional regulator A
Synonyms

1110033M05Rik, 2610318O14Rik, 53-E6, 9430037D06Rik, Fam172a, pEN87

Feature Type

protein coding gene
IDs

MGI:1915925
NCBI Gene: 68675
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr13:77856799-78314359 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 41.29 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

20465 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915925	protein coding gene	Chr13:77850152-78314359 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020782	protein coding gene	Chr13:78249692-78737146 (+)
A/J	MGP_AJ_G0020738	protein coding gene	Chr13:75576473-76042593 (+)
AKR/J	MGP_AKRJ_G0020711	protein coding gene	Chr13:77878020-78352190 (+)
BALB/cJ	MGP_BALBcJ_G0020734	protein coding gene	Chr13:76107913-76562277 (+)
C3H/HeJ	MGP_C3HHeJ_G0020528	protein coding gene	Chr13:77565381-78021590 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021171	protein coding gene	Chr13:80880336-81378526 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018739	protein coding gene	Chr13:72265642-72700964 (+)
CAST/EiJ	MGP_CASTEiJ_G0020046	protein coding gene	Chr13:76659758-77126230 (+)
CBA/J	MGP_CBAJ_G0020487	protein coding gene	Chr13:83935634-84442370 (+)
DBA/2J	MGP_DBA2J_G0020612	protein coding gene	Chr13:75293723-75740681 (+)
FVB/NJ	MGP_FVBNJ_G0020592	protein coding gene	Chr13:74371553-74833672 (+)
LP/J	MGP_LPJ_G0020685	protein coding gene	Chr13:78525335-79004423 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020621	protein coding gene	Chr13:82380498-82908083 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021211	protein coding gene	Chr13:77208608-77689134 (+)
PWK/PhJ	MGP_PWKPhJ_G0019799	protein coding gene	Chr13:74184088-74636623 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019622	protein coding gene	Chr13:73513823-73958960 (+)
WSB/EiJ	MGP_WSBEiJ_G0020103	protein coding gene	Chr13:77696716-78145701 (+)

Human Ortholog

ARB2A, ARB2 cotranscriptional regulator A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARB2A, ARB2 cotranscriptional regulator A
Synonyms

C5orf21, FAM172A, Toupee
Links

HGNC:25365

NCBI Gene ID: 83989

neXtProt AC: NX_Q8WUF8

UniProt: Q8WUF8
Chr Location

5q15; chr5:93617725-94111699 (-) GRCh38

MGI Vertebrate Homology

Arb2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARB2A
Gene Tree

Arb2a

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
41 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

5
Transgenic

1
Genomic Mutations

1 involving Arb2a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

1
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arb2a

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All Sequences

88
RefSeq

29
UniProt

7
CCDS

CCDS49317.1, CCDS49318.1, CCDS49319.1

Ensembl

ENSMUSG00000064138 (Evidence)
NCBI Gene

68675

			Length	Strain/Species	Flank
genomic	68675	NCBI Gene Model \| MGI Sequence Detail	457561	C57BL/6J	± kb
transcript	NM_138312	RefSeq \| MGI Sequence Detail	4036	C57BL/6
polypeptide	Q3TNH5	UniProt \| EBI \| MGI Sequence Detail	417	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000030727 cotranscriptional regulator ARB2A

(term hierarchy)
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR048263 Arb2
GlyGen

Q3TNH5 1 site

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All nucleic 14

cDNA 14

Microarray probesets 5

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MGI:1919788, MGI:2176345, MGI:2442300, MGI:7525412

Summaries

All 45

Developmental Gene Expression 4

Diseases 1

Gene Ontology 6

Phenotypes 16
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:363513 Chen H, et al., The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. Cell Rep. 2025 Feb 25;44(2):115231

TSS for Arb2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120446	Chr13:77856802-77856859 (+)	32 bp
Tssr4122	Chr13:77856862-77856869 (+)	67 bp
Tssr120447	Chr13:78024544-78024554 (+)	167,750 bp
Tssr120448	Chr13:78109445-78109447 (+)	252,647 bp
Tssr120452	Chr13:78266312-78266323 (+)	409,519 bp
Tssr120453	Chr13:78266349-78266356 (+)	409,554 bp
Tssr120454	Chr13:78266376-78266380 (+)	409,579 bp
Tssr120456	Chr13:78311216-78311225 (+)	454,422 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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