Nadk2 MGI Mouse Gene Detail - MGI:1915896 - NAD kinase 2, mitochondrial

Symbol

Nadk2
Name

NAD kinase 2, mitochondrial
Synonyms

1110020G09Rik, 4933430B08Rik, MNADK, Nadkd1

Feature Type

protein coding gene
IDs

MGI:1915896
NCBI Gene: 68646
Alliance

genome feature page

Sequence Map

Chr15:9071340-9110584 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 3.82 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

1079 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915896	protein coding gene	Chr15:9071340-9110979 (+)
129S1/SvImJ	ENSMUSG00200030353	protein coding gene	Chr15:6058876-6098532 (+)
A/J	ENSMUSG00195008908	protein coding gene	Chr15:5959062-6000587 (+)
AKR/J	ENSMUSG00220021157	protein coding gene	Chr15:5827366-5867009 (+)
BALB/cJ	ENSMUSG00180032686	protein coding gene	Chr15:5943338-5982978 (+)
C3H/HeJ	ENSMUSG00175029353	protein coding gene	Chr15:6125958-6165614 (+)
C57BL/6NJ	ENSMUSG00215013701	protein coding gene	Chr15:5955923-5995554 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019653	protein coding gene	Chr15:5552579-5593453 (+)
CAST/EiJ	ENSTCUG00005024315	protein coding gene	Chr15:5999862-6040936 (+)
CBA/J	ENSMUSG00210025104	protein coding gene	Chr15:6110997-6150652 (+)
DBA/2J	ENSMUSG00185029747	protein coding gene	Chr15:6042753-6082389 (+)
FVB/NJ	ENSMUSG00205019041	protein coding gene	Chr15:5960000-6001527 (+)
JF1/MsJ	ENSUMUG00000029594	protein coding gene	Chr15:6056415-6124977 (+)
LP/J	ENSMUSG00230019225	protein coding gene	Chr15:9551879-9591536 (+)
NOD/ShiLtJ	ENSMUSG00190009836	protein coding gene	Chr15:6029902-6071420 (+)
NZO/HlLtJ	ENSMUSG00225034190	protein coding gene	Chr15:9793102-9832734 (+)
PWK/PhJ	ENSLUMG00010031533	protein coding gene	Chr15:6107664-6173032 (+)
SPRET/EiJ	ENSMSPG00010030248	protein coding gene	Chr15:6130539-6175285 (+)
WSB/EiJ	ENSIUOG00005028338	protein coding gene	Chr15:5948422-5988071 (+)

Human Ortholog

NADK2, NAD kinase 2, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NADK2, NAD kinase 2, mitochondrial
Synonyms

C5orf33, DECRD, MNADK, NADKD1
Links

HGNC:26404

NCBI Gene ID: 133686

UniProt: Q4G0N4
Chr Location

5p13.2; chr5:36192589-36242279 (-) GRCh38

MGI Vertebrate Homology

Nadk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NADK2
Protein SuperFamily

Kin_ATP-NAD_euk
Gene Tree

Nadk2

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Phenotype Summary

26 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

2
Endonuclease-mediated

6
Gene trapped

6
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for knock-out allele exhibit increased serum lysine and carnitine levels, develop increased reactive oxygen species levels and hepatic steatosis on an atherogenic high-fat diet, and show impaired fasting-induced fatty acid oxidation.

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

1
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nadk2

ZFIN nadk2

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All Sequences

72
RefSeq

9
UniProt

8

Ensembl

ENSMUSG00000022253 (Evidence)
NCBI Gene

68646

			Length	Strain/Species	Flank
genomic	68646	NCBI Gene Model \| MGI Sequence Detail	39245	C57BL/6J	± kb
transcript	NM_001085410	RefSeq \| MGI Sequence Detail	3740	C57BL/6
polypeptide	Q8C5H8	UniProt \| EBI \| MGI Sequence Detail	452	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000029128 NAD kinase 2, mitochondrial

(term hierarchy)
EC

2.7.1.23
InterPro Domains

IPR017437 ATP-NAD kinase, PpnK-type, C-terminal

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR002504 NAD kinase

IPR012355 NAD kinase 2, mitochondrial

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
GlyGen

Q8C5H8 3 sites, 1 O-linked glycan (2 sites)

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 7

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MGI:1918451

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:374912 Zhang J, et al., Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm. Nat Cardiovasc Res. 2025 Mar;4(3):275-292

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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