Myct1 MGI Mouse Gene Detail - MGI:1915882

Symbol

Myct1
Name

myc target 1
Synonyms

1110020B04Rik, Mtmc1, MT-MC1

Feature Type

protein coding gene
IDs

MGI:1915882
NCBI Gene: 68632
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:5543728-5556789 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 1.99 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

527 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915882	protein coding gene	Chr10:5543728-5556904 (+)
129S1/SvImJ	ENSMUSG00200009829	protein coding gene	Chr10:2519043-2532217 (+)
A/J	ENSMUSG00195009784	protein coding gene	Chr10:2489601-2502781 (+)
AKR/J	ENSMUSG00220007305	protein coding gene	Chr10:2538867-2552046 (+)
BALB/cJ	ENSMUSG00180021727	protein coding gene	Chr10:2583763-2596941 (+)
C3H/HeJ	ENSMUSG00175011979	protein coding gene	Chr10:2544096-2557278 (+)
C57BL/6NJ	ENSMUSG00215004713	protein coding gene	Chr10:2479975-2493105 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015089	protein coding gene	Chr10:2287535-2299937 (+)
CAST/EiJ	ENSTCUG00005017904	protein coding gene	Chr10:2534688-2547570 (+)
CBA/J	ENSMUSG00210012523	protein coding gene	Chr10:2496953-2510135 (+)
DBA/2J	ENSMUSG00185009145	protein coding gene	Chr10:2550485-2563668 (+)
FVB/NJ	ENSMUSG00205007917	protein coding gene	Chr10:2542058-2555240 (+)
JF1/MsJ	ENSUMUG00000035587	protein coding gene	Chr10:2670071-2683069 (+)
LP/J	ENSMUSG00230014526	protein coding gene	Chr10:4182979-4196157 (+)
NOD/ShiLtJ	ENSMUSG00190024854	protein coding gene	Chr10:2490517-2503699 (+)
NZO/HlLtJ	ENSMUSG00225013467	protein coding gene	Chr10:8682118-8695299 (+)
PWK/PhJ	ENSLUMG00010020284	protein coding gene	Chr10:2519877-2532852 (+)
SPRET/EiJ	ENSMSPG00010006639	protein coding gene	Chr10:2743047-2754270 (+)
WSB/EiJ	ENSIUOG00005013828	protein coding gene	Chr10:2546910-2560095 (+)

Human Ortholog

MYCT1, MYC target 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYCT1, MYC target 1
Synonyms

MTLC
Links

HGNC:23172

NCBI Gene ID: 80177

UniProt: Q8N699
Chr Location

6q25.2; chr6:152697897-152747181 (+) GRCh38

MGI Vertebrate Homology

Myct1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYCT1
Gene Tree

Myct1

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit restricted tumor progression in various tumor models, showing reduced angiogenesis to tumors, enhanced high endothelial venule formation, and an antitumor immune microenvironment.

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All GO Annotations

6
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

642
Tissues

44
cDNA Data

30
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myct1

ZFIN myct1a

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS56681.1

Ensembl

ENSMUSG00000046916 (Evidence)
NCBI Gene

68632

			Length	Strain/Species	Flank
genomic	68632	NCBI Gene Model \| MGI Sequence Detail	13062	C57BL/6J	± kb
transcript	NM_026793	RefSeq \| MGI Sequence Detail	2792	C57BL/6
polypeptide	Q8R411	UniProt \| EBI \| MGI Sequence Detail	188	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010814 Myc target protein 1

(term hierarchy)
InterPro Domains

IPR029180 Myc target protein 1

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All nucleic 30

cDNA 30

Microarray probesets 5

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MGI:2143542, MGI:2143656

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:382751 Wetterwald L, et al., MYCT1-IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion. J Exp Med. 2026 May 4;223(5)

TSS for Myct1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92284	Chr10:5543718-5543739 (+)	1 bp
Tssr92285	Chr10:5543764-5543809 (+)	59 bp
Tssr92286	Chr10:5543810-5543821 (+)	88 bp
Tssr92287	Chr10:5543823-5543855 (+)	111 bp
Tssr92288	Chr10:5544772-5544775 (+)	1,046 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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