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Mthfd2l Gene Detail
Summary
  • Symbol
    Mthfd2l
  • Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
  • Synonyms
    1110019K23Rik, C630010D07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915871
    NCBI Gene: 665563
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91078976-91169227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2663 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915871
 protein coding gene Chr5:91078704-91169227 (+)
129S1/SvImJ ENSMUSG00200009022
 protein coding gene Chr5:86812216-86903459 (+)
A/J ENSMUSG00195025833
 protein coding gene Chr5:85979056-86070237 (+)
AKR/J ENSMUSG00220011863
 protein coding gene Chr5:86110403-86201471 (+)
BALB/cJ ENSMUSG00180020967
 protein coding gene Chr5:85824349-85915410 (+)
C3H/HeJ ENSMUSG00175041993
 protein coding gene Chr5:87919957-88011023 (+)
C57BL/6NJ ENSMUSG00215016487
 protein coding gene Chr5:86678174-86769349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027399
 protein coding gene Chr5:84075095-84167119 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210005674
 protein coding gene Chr5:86719741-86810794 (+)
DBA/2J ENSMUSG00185036705
 protein coding gene Chr5:88640682-88731726 (+)
FVB/NJ ENSMUSG00205024807
 protein coding gene Chr5:85540535-85631587 (+)
JF1/MsJ ENSUMUG00000027714
 protein coding gene Chr5:92921783-93015957 (+)
LP/J ENSMUSG00230027928
 protein coding gene Chr5:93338562-93429791 (+)
NOD/ShiLtJ ENSMUSG00190026441
 protein coding gene Chr5:85601771-85693285 (+)
NZO/HlLtJ ENSMUSG00225008861
 protein coding gene Chr5:98486069-98577309 (+)
PWK/PhJ ENSLUMG00010026326
 protein coding gene Chr5:85596275-85691074 (+)
SPRET/EiJ ENSMSPG00010034191
 protein coding gene Chr5:87985554-88071453 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
  • Links
    NCBI Gene ID: 441024
    UniProt: Q9H903

  • Chr Location
    4q13.3; chr4:74114174-74303099 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    159
  • cDNA Data
    29
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029376 Ensembl Gene Model | MGI Sequence Detail 90252 C57BL/6J ±  kb
    transcript ENSMUST00000071652 Ensembl | MGI Sequence Detail 2159 Not Applicable  
    polypeptide ENSMUSP00000071578 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030938 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
      (term hierarchy)
    • EC
      1.5.1.15, 1.5.1.5, 3.5.4.9
    • InterPro Domains
      IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily
      IPR036291 NAD(P)-binding domain superfamily
      IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
      IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
      IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 29
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:3529335
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory