Steap3 MGI Mouse Gene Detail - MGI:1915678

Symbol

Steap3
Name

STEAP family member 3
Synonyms

1010001D01Rik, pHyde

Feature Type

protein coding gene
IDs

MGI:1915678
NCBI Gene: 68428
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:120154137-120198810 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.66 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

320 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915678	protein coding gene	Chr1:120118487-120200435 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016405	protein coding gene	Chr1:122979382-123060997 (-)
A/J	MGP_AJ_G0016388	protein coding gene	Chr1:118569031-118650385 (-)
AKR/J	MGP_AKRJ_G0016353	protein coding gene	Chr1:122069717-122150001 (-)
BALB/cJ	MGP_BALBcJ_G0016348	protein coding gene	Chr1:118831175-118912274 (-)
C3H/HeJ	MGP_C3HHeJ_G0016174	protein coding gene	Chr1:122225259-122308666 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016809	protein coding gene	Chr1:127659928-127742057 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014522	protein coding gene	Chr1:112213776-112290970 (-)
CAST/EiJ	MGP_CASTEiJ_G0015755	protein coding gene	Chr1:121026724-121120098 (-)
CBA/J	MGP_CBAJ_G0016147	protein coding gene	Chr1:132088113-132173077 (-)
DBA/2J	MGP_DBA2J_G0016253	protein coding gene	Chr1:117592967-117673076 (-)
FVB/NJ	MGP_FVBNJ_G0016252	protein coding gene	Chr1:116347765-116428916 (-)
LP/J	MGP_LPJ_G0016324	protein coding gene	Chr1:124330450-124414807 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016277	protein coding gene	Chr1:137832564-137916297 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016845	protein coding gene	Chr1:121780344-121861935 (-)
PWK/PhJ	MGP_PWKPhJ_G0015541	protein coding gene	Chr1:116573172-116662002 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015329	protein coding gene	Chr1:120677489-120759582 (-)
WSB/EiJ	MGP_WSBEiJ_G0015817	protein coding gene	Chr1:121662080-121743923 (-)

Human Ortholog

STEAP3, STEAP3 metalloreductase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STEAP3, STEAP3 metalloreductase
Synonyms

AHMIO2, dudlin-2, dudulin-2, pHyde, STMP3, TSAP6
Links

HGNC:24592

NCBI Gene ID: 55240

neXtProt AC: NX_Q658P3

UniProt: Q658P3
Chr Location

2q14.2; chr2:119223831-119265652 (+) GRCh38

MGI Vertebrate Homology

Steap3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STEAP3
Gene Tree

Steap3

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References

1 with disease annotations

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Phenotype Summary

37 phenotypes from 4 alleles in 4 genetic backgrounds
13 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Steap3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in microcytic anemia, increased erythrocyte cell number, abnormal reticulocyte morphology, anisopoikilocytosis, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, and thrombocytosis.

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All GO Annotations

37
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

41
cDNA Data

28
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase steap3

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All Sequences

60
RefSeq

10
UniProt

4
CCDS

CCDS48343.1

Ensembl

ENSMUSG00000026389 (Evidence)
NCBI Gene

68428

			Length	Strain/Species	Flank
genomic	68428	NCBI Gene Model \| MGI Sequence Detail	44674	C57BL/6J	± kb
transcript	NM_001085409	RefSeq \| MGI Sequence Detail	3128	C57BL/6
polypeptide	Q8CI59	UniProt \| EBI \| MGI Sequence Detail	488	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015732 metalloreductase STEAP3

(term hierarchy)
EC

1.16.1.-
InterPro Domains

IPR013130 Ferric reductase transmembrane component-like domain

IPR036291 NAD(P)-binding domain superfamily

IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

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All nucleic 29

cDNA 29

Microarray probesets 4

Summaries

All 61

Developmental Gene Expression 3

Diseases 1

Gene Ontology 12

Phenotypes 27
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:307547 Miyata H, et al., Analysis of the sperm flagellar axoneme using gene-modified mice. Exp Anim. 2020 Nov 12;69(4):374-381

TSS for Steap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13250	Chr1:120198804-120198815 (-)	0 bp
Tssr13249	Chr1:120198754-120198763 (-)	51 bp
Tssr13248	Chr1:120197983-120198023 (-)	807 bp
Tssr13247	Chr1:120193102-120193107 (-)	5,705 bp
Tssr13246	Chr1:120193042-120193051 (-)	5,763 bp
Tssr13245	Chr1:120192977-120193034 (-)	5,804 bp
Tssr13244	Chr1:120186619-120186628 (-)	12,186 bp
Tssr13243	Chr1:120186598-120186615 (-)	12,203 bp
Tssr13242	Chr1:120186575-120186596 (-)	12,224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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