About   Help   FAQ
Toporsl Gene Detail
Summary
  • Symbol
    Toporsl
  • Name
    topoisomerase I binding, arginine/serine-rich like
  • Synonyms
    4930547C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915524
    NCBI Gene: 68274
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:52596274-52612430 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 28.40 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915524
 protein coding gene Chr4:52596274-52612430 (+)
129S1/SvImJ ENSMUSG00200002655
 protein coding gene Chr4:48663124-48679294 (+)
A/J ENSMUSG00195005817
 protein coding gene Chr4:49065503-49081696 (+)
AKR/J ENSMUSG00220002548
 protein coding gene Chr4:48834750-48850929 (+)
BALB/cJ ENSMUSG00180028595
 protein coding gene Chr4:48652818-48669012 (+)
C3H/HeJ ENSMUSG00175020924
 protein coding gene Chr4:48803964-48820152 (+)
C57BL/6NJ ENSMUSG00215021359
 protein coding gene Chr4:48649031-48665203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026020
 protein coding gene Chr4:46218292-46233147 (+)
CAST/EiJ ENSTCUG00005036922
 protein coding gene Chr4:48894964-48912706 (+)
CBA/J ENSMUSG00210019399
 protein coding gene Chr4:48562625-48579859 (+)
DBA/2J ENSMUSG00185030400
 protein coding gene Chr4:48911187-48928409 (+)
FVB/NJ ENSMUSG00205017794
 protein coding gene Chr4:48171658-48187833 (+)
JF1/MsJ ENSUMUG00000024250
 protein coding gene Chr4:49102212-49118324 (+)
LP/J ENSMUSG00230003044
 protein coding gene Chr4:52465687-52481859 (+)
NOD/ShiLtJ ENSMUSG00190024207
 protein coding gene Chr4:48768593-48784768 (+)
NZO/HlLtJ ENSMUSG00225002042
 protein coding gene Chr4:57061853-57078031 (+)
PWK/PhJ ENSLUMG00010012116
 protein coding gene Chr4:48040979-48057125 (+)
SPRET/EiJ ENSMSPG00010008921
 protein coding gene Chr4:49187042-49189646 (+)
WSB/EiJ ENSIUOG00005004103
 protein coding gene Chr4:48528673-48544862 (+)



Homology
more
  • Human Ortholog
    TOPORSLP, topoisomerase I binding, arginine and serine rich like, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOPORSLP, topoisomerase I binding, arginine and serine rich like, pseudogene
  • Synonyms
    TOPORSLP1
  • Links
    NCBI Gene ID: 347281

  • Chr Location
    9q31.1; chr9:104275298-104277399 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    4
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68274 NCBI Gene Model | MGI Sequence Detail 16157 C57BL/6J ±  kb
transcript NM_001356293 RefSeq | MGI Sequence Detail 2702 C57BL/6  
polypeptide NP_001343222 RefSeq | MGI Sequence Detail 683 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR058745 Topors, PWI-like domain
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory