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Cep70 Gene Detail
Summary
  • Symbol
    Cep70
  • Name
    centrosomal protein 70
  • Synonyms
    6720484E09Rik, C030018L16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915371
    NCBI Gene: 68121
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:99125420-99182457 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.45 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    440 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915371
protein coding gene Chr9:99065640-99205569 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035167
protein coding gene Chr9:100612872-100665393 (+)
A/J MGP_AJ_G0035148
protein coding gene Chr9:97054560-97105376 (+)
AKR/J MGP_AKRJ_G0035080
protein coding gene Chr9:99432489-99484357 (+)
BALB/cJ MGP_BALBcJ_G0035141
protein coding gene Chr9:96737236-96788693 (+)
C3H/HeJ MGP_C3HHeJ_G0034851
protein coding gene Chr9:99819159-99869752 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035661
protein coding gene Chr9:103495821-103550321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032560
protein coding gene Chr9:94800177-94850425 (+)
CAST/EiJ MGP_CASTEiJ_G0034162
protein coding gene Chr9:99633724-99687503 (+)
CBA/J MGP_CBAJ_G0034819
protein coding gene Chr9:107032643-107083968 (+)
DBA/2J MGP_DBA2J_G0034981
protein coding gene Chr9:96571387-96622185 (+)
FVB/NJ MGP_FVBNJ_G0034929
protein coding gene Chr9:95388486-95439994 (+)
LP/J MGP_LPJ_G0035057
protein coding gene Chr9:100859078-100913740 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034968
protein coding gene Chr9:108962225-109014924 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035683
protein coding gene Chr9:99679758-99731362 (+)
PWK/PhJ MGP_PWKPhJ_G0033869
protein coding gene Chr9:96786452-96840037 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033704
protein coding gene Chr9:99746458-99797543 (+)
WSB/EiJ MGP_WSBEiJ_G0034282
protein coding gene Chr9:99543646-99598023 (+)



Homology
more
  • Human Ortholog
    CEP70, centrosomal protein 70
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEP70, centrosomal protein 70
  • Synonyms
    BITE
  • Links
    NCBI Gene ID: 80321
    neXtProt AC: NX_Q8NHQ1
    UniProt: Q8NHQ1

  • Chr Location
    3q22.3; chr3:138494344-138594538 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility, azoospermia, teratozoospermia, and abnormal acrosome morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056267 Ensembl Gene Model | MGI Sequence Detail 57038 C57BL/6J ±  kb
    transcript ENSMUST00000093795 Ensembl | MGI Sequence Detail 2606 Not Applicable  
    polypeptide ENSMUSP00000091312 Ensembl | MGI Sequence Detail 616 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 39

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924987
    References
    more
    • Summaries
      All 35
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333258 Liu Q, et al., Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis. Cell Death Dis. 2021 May 12;12(5):478

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/13/2024
    MGI 6.23
    The Jackson Laboratory