Inafm2 Gene Detail

Summary

• Symbol
  Inafm2
• Name
  InaF motif containing 2
• Synonyms
  5430417L22Rik, ROME

• Feature Type
  protein coding gene
• IDs
  MGI:1915354
  NCBI Gene: 100043272
• Alliance
  genome feature page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr2:118576239-118579291 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 59.45 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  83 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915354	protein coding gene	Chr2:118576239-118579291 (+)
129S1/SvImJ	ENSMUSG00200045142	protein coding gene	Chr2:115521724-115524766 (+)
A/J	ENSMUSG00195022325	protein coding gene	Chr2:115569882-115572943 (+)
AKR/J	ENSMUSG00220035665	protein coding gene	Chr2:115448148-115451208 (+)
BALB/cJ	ENSMUSG00180038822	protein coding gene	Chr2:115375012-115378073 (+)
C3H/HeJ	ENSMUSG00175024887	protein coding gene	Chr2:115835194-115838236 (+)
C57BL/6NJ	ENSMUSG00215028178	protein coding gene	Chr2:115492957-115496008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003239	antisense lncRNA gene	Chr2:111562822-111565881 (+)
CAST/EiJ	ENSTCUG00005015794	protein coding gene	Chr2:114773981-114777036 (+)
CBA/J	ENSMUSG00210006931	protein coding gene	Chr2:115676160-115679202 (+)
DBA/2J	ENSMUSG00185047775	protein coding gene	Chr2:115371720-115374780 (+)
FVB/NJ	ENSMUSG00205033370	protein coding gene	Chr2:114586471-114589530 (+)
JF1/MsJ	ENSUMUG00000016204	protein coding gene	Chr2:115231465-115234517 (+)
LP/J	ENSMUSG00230018566	protein coding gene	Chr2:117181392-117184434 (+)
NOD/ShiLtJ	ENSMUSG00190032017	protein coding gene	Chr2:115604515-115607557 (+)
NZO/HlLtJ	ENSMUSG00225002491	protein coding gene	Chr2:125082840-125085882 (+)
PWK/PhJ	ENSLUMG00010041492	protein coding gene	Chr2:115136705-115139757 (+)
SPRET/EiJ	ENSMSPG00010032765	protein coding gene	Chr2:117543258-117546312 (+)
WSB/EiJ	ENSIUOG00005028330	protein coding gene	Chr2:115335944-115338986 (+)

Homology

• Human Ortholog
  INAFM2, InaF motif containing 2

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  INAFM2, InaF motif containing 2
  
• Synonyms
  LINC00984, OGU1
• Links
  HGNC:35165

  NCBI Gene ID: 100505573

  UniProt: P0DMQ5

  
  
• Chr Location
  chr15:40323692-40326715 (+)  GRCh38

---

• MGI Vertebrate Homology
  Inafm2 stringent orthology
  1 human;1 mouse;1 zebrafish
  
• HCOP
  vertebrate homology predictions: INAFM2
• Gene Tree
  Inafm2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving Inafm2
• Find Mice (IMSR)
  1 strains or lines available

Expression

• Assay Results
  618
• Tissues
  16
• cDNA Data
  3
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS89539.1

• Ensembl
  ENSMUSG00000074918 (Evidence)
• NCBI Gene
  100043272

Representative Sequences			Length	Strain/Species
genomic	100043272	NCBI Gene Model | MGI Sequence Detail	3053	C57BL/6J
transcript	NM_001301269	RefSeq | MGI Sequence Detail	3053	C57BL/6
polypeptide	NP_001288198	RefSeq | MGI Sequence Detail	152	C57BL/6

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR029162 TRP-interacting helix, InaF motif

Molecular
Reagents

• All nucleic 4

  cDNA 3

  Other 1

  Antibodies 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:3708665

References

• Summaries
  All 20

  Developmental Gene Expression 1

  Phenotypes 5
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:385698 Molotkova A, et al., ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis. Cancer Res Commun. 2026 Mar 1;6(3):477-499

TSS for Inafm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19569	Chr2:118576219-118576254 (+)	-2 bp
Tssr19570	Chr2:118576258-118576280 (+)	30 bp
Tssr19571	Chr2:118577466-118577470 (+)	1,229 bp
Tssr19572	Chr2:118577744-118577746 (+)	1,506 bp