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Eef1akmt1 Gene Detail
Summary
  • Symbol
    Eef1akmt1
  • Name
    EEF1A alpha lysine methyltransferase 1
  • Synonyms
    2510005D08Rik, Ayu21-96, GtAyu21-96, Gt(Ayu21)96Imeg, N6amt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915293
    NCBI Gene: 68043
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:57787052-57809039 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    685 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915293
 protein coding gene Chr14:57787052-57809069 (-)
129S1/SvImJ ENSMUSG00200039939
 protein coding gene Chr14:46372308-46394329 (-)
A/J ENSMUSG00195027740
 protein coding gene Chr14:46587563-46609589 (-)
AKR/J ENSMUSG00220025760
 protein coding gene Chr14:45914526-45936547 (-)
BALB/cJ ENSMUSG00180051594
 protein coding gene Chr14:46209588-46231612 (-)
C3H/HeJ ENSMUSG00175047746
 protein coding gene Chr14:47916124-47938142 (-)
C57BL/6NJ ENSMUSG00215046003
 protein coding gene Chr14:46110262-46132283 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019351
 protein coding gene Chr14:48796065-48817978 (-)
CAST/EiJ ENSTCUG00005048789
 protein coding gene Chr14:47889671-47910122 (-)
CBA/J ENSMUSG00210043204
 protein coding gene Chr14:46577944-46599960 (-)
DBA/2J ENSMUSG00185031370
 protein coding gene Chr14:51712074-51732114 (-)
FVB/NJ ENSMUSG00205021968
 protein coding gene Chr14:45979955-46001976 (-)
JF1/MsJ ENSUMUG00000023660
 protein coding gene Chr14:62883160-62903231 (-)
LP/J ENSMUSG00230033090
 protein coding gene Chr14:63741305-63763320 (-)
NOD/ShiLtJ ENSMUSG00190038471
 protein coding gene Chr14:46344269-46366284 (-)
NZO/HlLtJ ENSMUSG00225045062
 protein coding gene Chr14:54034611-54056630 (-)
PWK/PhJ ENSLUMG00010039213
 protein coding gene Chr14:45803908-45825915 (-)
SPRET/EiJ ENSMSPG00010039802
 protein coding gene Chr14:49325665-49345639 (-)
WSB/EiJ ENSIUOG00005040471
 protein coding gene Chr14:45773046-45793065 (-)



Homology
more
  • Human Ortholog
    EEF1AKMT1, EEF1A lysine methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEF1AKMT1, EEF1A lysine methyltransferase 1
  • Synonyms
    eEF1A-KMT, ESP13, N6AMT2
  • Links
    NCBI Gene ID: 221143
    UniProt: Q8WVE0

  • Chr Location
    13q12.11; chr13:20727970-20773961 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    26
  • Targeted
    2
  • Genomic Mutations
    1 involving Eef1akmt1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    32 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    53
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68043 NCBI Gene Model | MGI Sequence Detail 21988 C57BL/6J ±  kb
transcript NM_026526 RefSeq | MGI Sequence Detail 852 C57BL/6  
polypeptide Q9CY45 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010943 EEF1A lysine methyltransferase 1
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR002052 DNA methylase, N-6 adenine-specific, conserved site
    IPR041370 Methyltransferase EEF1AKMT1/ZCCHC4
    IPR019369 Protein-lysine N-methyltransferase Efm5/EEF1AKMT1
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145784, MGI:3629757
References
more
  • Summaries
    All 43
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory