U2surp MGI Mouse Gene Detail - MGI:1915208 - U2 snRNP-associated SURP domain containing

Symbol

U2surp
Name

U2 snRNP-associated SURP domain containing
Synonyms

2610101N10Rik

Feature Type

protein coding gene
IDs

MGI:1915208
NCBI Gene: 67958
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:95338951-95394049 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 50.11 cM, cytoband E4
Mapping Data

3 experiments

SNPs within 2kb

1287 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915208	protein coding gene	Chr9:95338947-95394049 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035134	protein coding gene	Chr9:96569715-96633219 (-)
A/J	MGP_AJ_G0035115	protein coding gene	Chr9:93224948-93282815 (-)
AKR/J	MGP_AKRJ_G0035047	protein coding gene	Chr9:95474997-95534316 (-)
BALB/cJ	MGP_BALBcJ_G0035108	protein coding gene	Chr9:92911075-92970091 (-)
C3H/HeJ	MGP_C3HHeJ_G0034818	protein coding gene	Chr9:95913583-95973844 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035628	protein coding gene	Chr9:99330019-99396188 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032530	protein coding gene	Chr9:91056792-91108399 (-)
CAST/EiJ	MGP_CASTEiJ_G0034130	protein coding gene	Chr9:95638190-95697128 (-)
CBA/J	MGP_CBAJ_G0034786	protein coding gene	Chr9:102777019-102840891 (-)
DBA/2J	MGP_DBA2J_G0034948	protein coding gene	Chr9:92753215-92808826 (-)
FVB/NJ	MGP_FVBNJ_G0034896	protein coding gene	Chr9:91606878-91662324 (-)
LP/J	MGP_LPJ_G0035027	protein coding gene	Chr9:96832958-96892158 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034935	protein coding gene	Chr9:104789001-104859131 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035650	protein coding gene	Chr9:95689383-95749475 (-)
PWK/PhJ	MGP_PWKPhJ_G0033837	protein coding gene	Chr9:92897407-92954797 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033672	protein coding gene	Chr9:95704548-95762011 (-)
WSB/EiJ	MGP_WSBEiJ_G0034250	protein coding gene	Chr9:95567114-95625722 (-)

Human Ortholog

U2SURP, U2 snRNP associated SURP domain containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

U2SURP, U2 snRNP associated SURP domain containing
Synonyms

fSAPa, SR140
Links

HGNC:30855

NCBI Gene ID: 23350

neXtProt AC: NX_O15042

UniProt: O15042
Chr Location

3q23; chr3:142964497-143060725 (+) GRCh38

MGI Vertebrate Homology

U2surp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: U2SURP
Gene Tree

U2surp

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

52
Targeted

2
Genomic Mutations

1 involving U2surp
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase u2surp

ZFIN u2surp

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All Sequences

73
RefSeq

16
UniProt

4
CCDS

CCDS40727.1, CCDS52889.1, CCDS90640.1

Ensembl

ENSMUSG00000032407 (Evidence)
NCBI Gene

67958

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032407	Ensembl Gene Model \| MGI Sequence Detail	55099	C57BL/6J	± kb
transcript	ENSMUST00000079659	Ensembl \| MGI Sequence Detail	7630	Not Applicable
polypeptide	ENSMUSP00000078602	Ensembl \| MGI Sequence Detail	1029	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015604 U2 snRNP-associated SURP motif-containing protein

(term hierarchy)
InterPro Domains

IPR006569 CID domain

IPR008942 ENTH/VHS

IPR013170 mRNA splicing factor Cwf21 domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR035009 SR140, RNA recognition motif

IPR051485 SR-related and CTD-associated factor

IPR000061 SWAP/Surp

IPR035967 SWAP/Surp superfamily

IPR047488 U2-associated protein SR140, cwf21 domain
GlyGen

Q6NV83 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 6

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MGI:2143220

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for U2surp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90920	Chr9:95393950-95393961 (-)	93 bp
Tssr90919	Chr9:95393910-95393945 (-)	121 bp
Tssr90918	Chr9:95371908-95371930 (-)	22,130 bp
Tssr90917	Chr9:95371855-95371872 (-)	22,185 bp
Tssr90916	Chr9:95356517-95356538 (-)	37,521 bp
Tssr90915	Chr9:95354145-95354173 (-)	39,890 bp
Tssr90914	Chr9:95344654-95344658 (-)	49,393 bp
Tssr90913	Chr9:95342148-95342152 (-)	51,899 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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