Zcchc3 MGI Mouse Gene Detail - MGI:1915167 - zinc finger, CCHC domain containing 3

Symbol

Zcchc3
Name

zinc finger, CCHC domain containing 3
Synonyms

2810406K24Rik

Feature Type

protein coding gene
IDs

MGI:1915167
NCBI Gene: 67917
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:152253875-152256711 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.98 cM
Mapping Data

1 experiment

SNPs within 2kb

120 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915167	protein coding gene	Chr2:152253875-152256947 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026659	protein coding gene	Chr2:156950011-156955345 (-)
A/J	MGP_AJ_G0026625	protein coding gene	Chr2:150698092-150701100 (-)
AKR/J	MGP_AKRJ_G0026595	protein coding gene	Chr2:155096424-155099495 (-)
BALB/cJ	MGP_BALBcJ_G0026634	protein coding gene	Chr2:151007673-151010746 (-)
C3H/HeJ	MGP_C3HHeJ_G0026377	protein coding gene	Chr2:155480218-155483287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027083	protein coding gene	Chr2:161534722-161539597 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024454	protein coding gene	Chr2:144287115-144290168 (-)
CAST/EiJ	MGP_CASTEiJ_G0025838	protein coding gene	Chr2:155713660-155716720 (-)
CBA/J	MGP_CBAJ_G0026355	protein coding gene	Chr2:167445988-167449051 (-)
DBA/2J	MGP_DBA2J_G0026491	protein coding gene	Chr2:149914141-149917108 (-)
FVB/NJ	MGP_FVBNJ_G0026457	protein coding gene	Chr2:148355551-148360551 (-)
LP/J	MGP_LPJ_G0026595	protein coding gene	Chr2:157111500-157114565 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026478	protein coding gene	Chr2:171553329-171557928 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027139	protein coding gene	Chr2:154981926-154985222 (-)
PWK/PhJ	MGP_PWKPhJ_G0025572	protein coding gene	Chr2:149430692-149433750 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025375	protein coding gene	Chr2:153804835-153808461 (-)
WSB/EiJ	MGP_WSBEiJ_G0025908	protein coding gene	Chr2:155903267-155906332 (-)

Human Ortholog

ZCCHC3, zinc finger CCHC-type containing 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZCCHC3, zinc finger CCHC-type containing 3
Synonyms

C20orf99
Links

HGNC:16230

NCBI Gene ID: 85364

UniProt: Q9NUD5
Chr Location

20p13; chr20:297570-300321 (+) GRCh38

MGI Vertebrate Homology

Zcchc3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZCCHC3
Gene Tree

Zcchc3

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Genomic Mutations

2 involving Zcchc3
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are more susceptible to lethal infection by DNA viruses.

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All GO Annotations

14
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

15
cDNA Data

62
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS16884.1

Ensembl

ENSMUSG00000074682 (Evidence)
NCBI Gene

67917

			Length	Strain/Species	Flank
genomic	67917	NCBI Gene Model \| MGI Sequence Detail	2837	C57BL/6J	± kb
transcript	NM_175126	RefSeq \| MGI Sequence Detail	2837	C57BL/6
polypeptide	Q8BPK2	UniProt \| EBI \| MGI Sequence Detail	400	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030903 zinc finger CCHC domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR042509 Zinc finger CCHC domain-containing protein 3

IPR001878 Zinc finger, CCHC-type

IPR036875 Zinc finger, CCHC-type superfamily
GlyGen

Q8BPK2 1 site

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All nucleic 62

cDNA 62

Microarray probesets 5

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zcchc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26824	Chr2:152256759-152256781 (-)	-59 bp
Tssr26823	Chr2:152256738-152256754 (-)	-35 bp
Tssr26822	Chr2:152256692-152256729 (-)	0 bp
Tssr26821	Chr2:152256659-152256675 (-)	44 bp
Tssr26820	Chr2:152255406-152255409 (-)	1,303 bp
Tssr26819	Chr2:152255188-152255231 (-)	1,501 bp
Tssr26818	Chr2:152254840-152254845 (-)	1,868 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24