Zcchc3 MGI Mouse Gene Detail - MGI:1915167 - zinc finger, CCHC domain containing 3

Symbol

Zcchc3
Name

zinc finger, CCHC domain containing 3
Synonyms

2810406K24Rik

Feature Type

protein coding gene
IDs

MGI:1915167
NCBI Gene: 67917
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:152253875-152256947 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.98 cM
Mapping Data

1 experiment

SNPs within 2kb

35 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915167	protein coding gene	Chr2:152253875-152256964 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026659	protein coding gene	Chr2:156950011-156955345 (-)
A/J	MGP_AJ_G0026625	protein coding gene	Chr2:150698092-150701100 (-)
AKR/J	MGP_AKRJ_G0026595	protein coding gene	Chr2:155096424-155099495 (-)
BALB/cJ	MGP_BALBcJ_G0026634	protein coding gene	Chr2:151007673-151010746 (-)
C3H/HeJ	MGP_C3HHeJ_G0026377	protein coding gene	Chr2:155480218-155483287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027083	protein coding gene	Chr2:161534722-161539597 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024454	protein coding gene	Chr2:144287115-144290168 (-)
CAST/EiJ	MGP_CASTEiJ_G0025838	protein coding gene	Chr2:155713660-155716720 (-)
CBA/J	MGP_CBAJ_G0026355	protein coding gene	Chr2:167445988-167449051 (-)
DBA/2J	MGP_DBA2J_G0026491	protein coding gene	Chr2:149914141-149917108 (-)
FVB/NJ	MGP_FVBNJ_G0026457	protein coding gene	Chr2:148355551-148360551 (-)
LP/J	MGP_LPJ_G0026595	protein coding gene	Chr2:157111500-157114565 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026478	protein coding gene	Chr2:171553329-171557928 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027139	protein coding gene	Chr2:154981926-154985222 (-)
PWK/PhJ	MGP_PWKPhJ_G0025572	protein coding gene	Chr2:149430692-149433750 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025375	protein coding gene	Chr2:153804835-153808461 (-)
WSB/EiJ	MGP_WSBEiJ_G0025908	protein coding gene	Chr2:155903267-155906332 (-)

Human Ortholog

ZCCHC3, zinc finger CCHC-type containing 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZCCHC3, zinc finger CCHC-type containing 3
Synonyms

C20orf99
Links

HGNC:16230

NCBI Gene ID: 85364

neXtProt AC: NX_Q9NUD5

UniProt: Q9NUD5
Chr Location

20p13; chr20:297563-300321 (+) GRCh38.p7

Alliance of Genome Resources

Zcchc3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZCCHC3
Gene Tree

Zcchc3

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Genomic Mutations

2 involving Zcchc3
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are more susceptible to lethal infection by DNA viruses.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

15
cDNA Data

62
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Zcchc3 interacts with 244 markers (Mir7-1, Mir10a, Mir10b, ...) View All

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS16884.1

Ensembl

ENSMUSG00000074682 (Evidence)
NCBI Gene

67917

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074682	Ensembl Gene Model \| MGI Sequence Detail	3073	C57BL/6J	± kb
transcript	ENSMUST00000099207	Ensembl \| MGI Sequence Detail	3073	Not Applicable
polypeptide	ENSMUSP00000096813	Ensembl \| MGI Sequence Detail	400	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030903 zinc finger CCHC domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR042509 Zinc finger CCHC domain-containing protein 3

IPR001878 Zinc finger, CCHC-type

IPR036875 Zinc finger, CCHC-type superfamily

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All nucleic 62

cDNA 62

Microarray probesets 5

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 7
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:319508 Zang R, et al., ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3. J Mol Cell Biol. 2020 May 18;12(4):251-262

TSS for Zcchc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26824	Chr2:152256759-152256781 (-)	177 bp
Tssr26823	Chr2:152256738-152256754 (-)	201 bp
Tssr26822	Chr2:152256692-152256729 (-)	236 bp
Tssr26821	Chr2:152256659-152256675 (-)	280 bp
Tssr26820	Chr2:152255406-152255409 (-)	1,539 bp
Tssr26819	Chr2:152255188-152255231 (-)	1,737 bp
Tssr26818	Chr2:152254840-152254845 (-)	2,104 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 03/21/2023 MGI 6.22