Tmem33 MGI Mouse Gene Detail - MGI:1915128

Symbol

Tmem33
Name

transmembrane protein 33
Synonyms

1110006G02Rik, 1600019D15Rik, 2410089A21Rik, 2700052H22Rik, 5430406L04Rik

Feature Type

protein coding gene
IDs

MGI:1915128
NCBI Gene: 67878
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:67417908-67448804 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 36.00 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

779 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915128	protein coding gene	Chr5:67417908-67448804 (+)
129S1/SvImJ	ENSMUSG00200035013	protein coding gene	Chr5:63055056-63079244 (+)
A/J	ENSMUSG00195033328	protein coding gene	Chr5:62409360-62433548 (+)
AKR/J	ENSMUSG00220003441	protein coding gene	Chr5:62547269-62571457 (+)
BALB/cJ	ENSMUSG00180020848	protein coding gene	Chr5:62202151-62226340 (+)
C3H/HeJ	ENSMUSG00175024381	protein coding gene	Chr5:64229643-64253833 (+)
C57BL/6NJ	ENSMUSG00215005024	protein coding gene	Chr5:62965454-62996219 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027264	protein coding gene	Chr5:60578839-60601837 (+)
CAST/EiJ	ENSTCUG00005031298	protein coding gene	Chr5:62126343-62150551 (+)
CBA/J	ENSMUSG00210023264	protein coding gene	Chr5:63142509-63166697 (+)
DBA/2J	ENSMUSG00185005516	protein coding gene	Chr5:65000028-65024216 (+)
FVB/NJ	ENSMUSG00205028334	protein coding gene	Chr5:61952419-61976655 (+)
JF1/MsJ	ENSUMUG00000012888	protein coding gene	Chr5:69513483-69539038 (+)
LP/J	ENSMUSG00230008110	protein coding gene	Chr5:69667604-69691792 (+)
NOD/ShiLtJ	ENSMUSG00190004141	protein coding gene	Chr5:62134026-62158213 (+)
NZO/HlLtJ	ENSMUSG00225008445	protein coding gene	Chr5:74773624-74797812 (+)
PWK/PhJ	ENSLUMG00010011631	protein coding gene	Chr5:62125112-62150701 (+)
SPRET/EiJ	ENSMSPG00010027339	protein coding gene	Chr5:63912445-63931652 (+)
WSB/EiJ	ENSIUOG00005016383	protein coding gene	Chr5:65110453-65134776 (+)

Human Ortholog

TMEM33, transmembrane protein 33

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM33, transmembrane protein 33
Synonyms

1600019D15Rik, Pom33, SHINC-3, SHINC3
Links

HGNC:25541

NCBI Gene ID: 55161

UniProt: P57088
Chr Location

4p13; chr4:41934403-41960803 (+) GRCh38

MGI Vertebrate Homology

Tmem33 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM33
Gene Tree

Tmem33

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

3
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Tmem33
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

689
Tissues

36
cDNA Data

25
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem33

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All Sequences

82
RefSeq

6
UniProt

9
CCDS

CCDS19317.1, CCDS51511.1

Ensembl

ENSMUSG00000037720 (Evidence)
NCBI Gene

67878

			Length	Strain/Species	Flank
genomic	67878	NCBI Gene Model \| MGI Sequence Detail	30897	C57BL/6J	± kb
transcript	NM_001285452	RefSeq \| MGI Sequence Detail	6404	C57BL/6
polypeptide	Q9CR67	UniProt \| EBI \| MGI Sequence Detail	247	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000031406 transmembrane protein 33

(term hierarchy)
InterPro Domains

IPR051645 PER33/POM33 transmembrane regulator

IPR005344 TMEM33/Pom33 family
GlyGen

Q9CR67 1 site, 1 O-linked glycan (1 site)

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All nucleic 25

cDNA 25

Microarray probesets 12

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MGI:1915829, MGI:1921744, MGI:1924069, MGI:1925743, MGI:2140828, MGI:2140867, MGI:3035502

Summaries

All 64

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem33:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46566	Chr5:67418014-67418035 (+)	117 bp
Tssr46567	Chr5:67418040-67418054 (+)	139 bp
Tssr1501	Chr5:67418059-67418063 (+)	153 bp
Tssr46568	Chr5:67418068-67418084 (+)	168 bp
Tssr46569	Chr5:67418087-67418122 (+)	197 bp
Tssr46570	Chr5:67418137-67418157 (+)	239 bp
Tssr46571	Chr5:67418161-67418170 (+)	258 bp
Tssr46572	Chr5:67418268-67418313 (+)	383 bp
Tssr46573	Chr5:67444784-67444789 (+)	26,879 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24