Naa20 MGI Mouse Gene Detail - MGI:1915127 - N(alpha)-acetyltransferase 20, NatB catalytic subunit

Symbol

Naa20
Name

N(alpha)-acetyltransferase 20, NatB catalytic subunit
Synonyms

1500004D14Rik, 2900026I01Rik, D2Ertd186e, Nat5

Feature Type

protein coding gene
IDs

MGI:1915127
NCBI Gene: 67877
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:145744019-145758345 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 71.28 cM, cytoband H1
Mapping Data

4 experiments

SNPs within 2kb

421 from dbSNP Build 142
Strain Annotations

21

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915127	protein coding gene	Chr2:145743454-145758345 (+)
129S1/SvImJ	ENSMUSG00200025901	protein coding gene	Chr2:142857608-142864718 (+)
129S1/SvImJ	ENSMUSGG00200054593	protein coding gene	Chr2:142865987-142866842 (+)
A/J	ENSMUSGG00195055182	protein coding gene	Chr2:142991732-142992605 (+)
AKR/J	ENSMUSGG00220054893	protein coding gene	Chr2:142575588-142576443 (+)
AKR/J	ENSMUSG00220044244	protein coding gene	Chr2:142567207-142574319 (+)
BALB/cJ	ENSMUSGG00180055245	protein coding gene	Chr2:142653565-142654438 (+)
C3H/HeJ	ENSMUSGG00175054590	protein coding gene	Chr2:143200606-143201479 (+)
C57BL/6NJ	ENSMUSG00215027467	protein coding gene	Chr2:142707185-142714295 (+)
C57BL/6NJ	ENSMUSGG00215055319	protein coding gene	Chr2:142715564-142716419 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024393	protein coding gene	Chr2:138121984-138135676 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210055050	protein coding gene	Chr2:143119818-143120691 (+)
DBA/2J	ENSMUSG00185047466	protein coding gene	Chr2:142736158-142743268 (+)
DBA/2J	ENSMUSGG00185057573	protein coding gene	Chr2:142744537-142745392 (+)
FVB/NJ	ENSMUSGG00205054047	protein coding gene	Chr2:141928300-141929173 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230029434	protein coding gene	Chr2:144440191-144447301 (+)
LP/J	ENSMUSGG00230055566	protein coding gene	Chr2:144448570-144449425 (+)
NOD/ShiLtJ	ENSMUSGG00190055046	protein coding gene	Chr2:142788094-142788967 (+)
NZO/HlLtJ	ENSMUSGG00225055319	protein coding gene	Chr2:152436869-152437724 (+)
NZO/HlLtJ	ENSMUSG00225001165	protein coding gene	Chr2:152428490-152435600 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010023896	protein coding gene	Chr2:145044502-145057975 (+)
WSB/EiJ	no annotation

Human Ortholog

NAA20, N-alpha-acetyltransferase 20, NatB catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAA20, N-alpha-acetyltransferase 20, NatB catalytic subunit
Synonyms

dJ1002M8.1, MRT73, NAT3, NAT3P, NAT5, NAT5P
Links

HGNC:15908

NCBI Gene ID: 51126

UniProt: P61599
Chr Location

20p11.23; chr20:20017290-20033655 (+) GRCh38

MGI Vertebrate Homology

Naa20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAA20
Gene Tree

Naa20

Diseases

1 with human NAA20 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 73 IDs autosomal recessive intellectual developmental disorder 73 DOID:0081233 OMIM:619717

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

29
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Naa20
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

687
Tissues

56
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase naa20

ZFIN naa20

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All Sequences

65
RefSeq

5
UniProt

8
CCDS

CCDS16827.1, CCDS50735.1

Ensembl

ENSMUSG00000002728 (Evidence)
NCBI Gene

67877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002728	Ensembl Gene Model \| MGI Sequence Detail	14327	C57BL/6J	± kb
transcript	ENSMUST00000002805	Ensembl \| MGI Sequence Detail	1172	Not Applicable
polypeptide	ENSMUSP00000002805	Ensembl \| MGI Sequence Detail	188	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011002 N-alpha-acetyltransferase 20

(term hierarchy)
EC

2.3.1.254
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000182 GNAT domain

IPR051646 N-terminal NatB acetyltransferase catalytic subunit
GlyGen

P61600 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Antibodies 1

Microarray probesets 4

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MGI:1098563, MGI:1920128, MGI:2139211

Summaries

All 59

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 20
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:370588 Guedes JP, et al., NatB Protects Procaspase-8 from UBR4-Mediated Degradation and Is Required for Full Induction of the Extrinsic Apoptosis Pathway. Mol Cell Biol. 2024;44(9):358-371

TSS for Naa20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20600	Chr2:145745142-145745147 (+)	1,126 bp
Tssr20601	Chr2:145745154-145745220 (+)	1,168 bp
Tssr20602	Chr2:145745810-145745823 (+)	1,798 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24