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Rprm Gene Detail
Summary
  • Symbol
    Rprm
  • Name
    reprimo, TP53 dependent G2 arrest mediator candidate
  • Synonyms
    2410012A13Rik, Reprimo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915124
    NCBI Gene: 67874
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:53974105-53975564 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 30.69 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915124
 protein coding gene Chr2:53974105-53975564 (-)
129S1/SvImJ ENSMUSG00200002221
 protein coding gene Chr2:50986248-50987707 (-)
A/J ENSMUSG00195004859
 protein coding gene Chr2:51138259-51139718 (-)
AKR/J ENSMUSG00220007260
 protein coding gene Chr2:51214423-51215882 (-)
BALB/cJ ENSMUSG00180019096
 protein coding gene Chr2:51103850-51105309 (-)
C3H/HeJ ENSMUSG00175013683
 protein coding gene Chr2:51158382-51159841 (-)
C57BL/6NJ ENSMUSG00215008280
 protein coding gene Chr2:51130121-51131580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023563
 protein coding gene Chr2:49266464-49267928 (-)
CAST/EiJ ENSTCUG00005001285
 protein coding gene Chr2:50584794-50586254 (-)
CBA/J ENSMUSG00210031662
 protein coding gene Chr2:51176218-51177677 (-)
DBA/2J ENSMUSG00185007678
 protein coding gene Chr2:51038955-51040414 (-)
FVB/NJ ENSMUSG00205017996
 protein coding gene Chr2:50580403-50581862 (-)
JF1/MsJ ENSUMUG00000022173
 protein coding gene Chr2:50822409-50823868 (-)
LP/J ENSMUSG00230001294
 protein coding gene Chr2:52918357-52919816 (-)
NOD/ShiLtJ ENSMUSG00190027022
 protein coding gene Chr2:51101027-51102486 (-)
NZO/HlLtJ ENSMUSG00225000500
 protein coding gene Chr2:60636015-60637474 (-)
PWK/PhJ ENSLUMG00010004453
 protein coding gene Chr2:50959571-50961030 (-)
SPRET/EiJ ENSMSPG00010011357
 protein coding gene Chr2:51974699-51976158 (-)
WSB/EiJ ENSIUOG00005027695
 protein coding gene Chr2:51089238-51090697 (-)



Homology
more
  • Human Ortholog
    RPRM, reprimo, TP53 dependent G2 arrest mediator homolog
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPRM, reprimo, TP53 dependent G2 arrest mediator homolog
  • Synonyms
    REPRIMO
  • Links
    NCBI Gene ID: 56475
    UniProt: Q9NS64

  • Chr Location
    2q23.3; chr2:153477338-153478762 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased resistance to gamma radiation induced intestinal tumors and reduced lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    49
  • cDNA Data
    28
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67874 NCBI Gene Model | MGI Sequence Detail 1460 C57BL/6J ±  kb
transcript NM_023396 RefSeq | MGI Sequence Detail 1460 C57BL/6  
polypeptide Q9JJ72 UniProt | EBI | MGI Sequence Detail 109 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 28
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 49
    Developmental Gene Expression 14
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:73429 Ohki R, et al., Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. J Biol Chem. 2000 Jul 28;275(30):22627-30
  • Latest
    J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory