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Sncaip Gene Detail
Summary
  • Symbol
    Sncaip
  • Name
    synuclein, alpha interacting protein (synphilin)
  • Synonyms
    4933427B05Rik, synphilin-1, SYPH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915097
    NCBI Gene: 67847
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:52900872-53049007 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 28.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3656 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915097
 protein coding gene Chr18:52900781-53049007 (+)
129S1/SvImJ ENSMUSG00200029310
 protein coding gene Chr18:49926799-50082010 (+)
A/J ENSMUSG00195024280
 protein coding gene Chr18:50100123-50248618 (+)
AKR/J ENSMUSG00220021003
 protein coding gene Chr18:50045197-50193657 (+)
BALB/cJ ENSMUSG00180007661
 protein coding gene Chr18:50660378-50808835 (+)
C3H/HeJ ENSMUSG00175010806
 protein coding gene Chr18:50269410-50417844 (+)
C57BL/6NJ ENSMUSG00215006797
 protein coding gene Chr18:49622461-49770713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022276
 protein coding gene Chr18:49693576-49837332 (+)
CAST/EiJ ENSTCUG00005013661
 protein coding gene Chr18:49494042-49635890 (+)
CBA/J ENSMUSG00210022448
 protein coding gene Chr18:50203030-50351510 (+)
DBA/2J ENSMUSG00185027162
 protein coding gene Chr18:50123004-50271508 (+)
FVB/NJ ENSMUSG00205012620
 protein coding gene Chr18:49564047-49710796 (+)
JF1/MsJ ENSUMUG00000026034
 protein coding gene Chr18:50034080-50179309 (+)
LP/J ENSMUSG00230011219
 protein coding gene Chr18:52112857-52261295 (+)
NOD/ShiLtJ ENSMUSG00190023870
 protein coding gene Chr18:49820607-49969060 (+)
NZO/HlLtJ ENSMUSG00225033996
 protein coding gene Chr18:52026612-52175051 (+)
PWK/PhJ ENSLUMG00010020915
 protein coding gene Chr18:50195272-50340079 (+)
SPRET/EiJ ENSMSPG00010012203
 protein coding gene Chr18:50530405-50669733 (+)
WSB/EiJ ENSIUOG00005008856
 protein coding gene Chr18:49726468-49874704 (+)



Homology
more
  • Human Ortholog
    SNCAIP, synuclein alpha interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNCAIP, synuclein alpha interacting protein
  • Synonyms
    Sph1, SYPH1
  • Links
    NCBI Gene ID: 9627
    UniProt: Q9Y6H5

  • Chr Location
    5q23.2; chr5:122311353-122464224 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    89
  • cDNA Data
    12
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67847 NCBI Gene Model | MGI Sequence Detail 148136 C57BL/6J ±  kb
transcript NM_001403648 RefSeq | MGI Sequence Detail 4314 C57BL/6  
polypeptide Q99ME3 UniProt | EBI | MGI Sequence Detail 962 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 12
    Primer pair 1
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918444, MGI:2147384
References
more
  • Summaries
    All 67
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:384957 Farhoud M, et al., Synphilin-1 Is Essential for Cytoskeletal Integrity of Brain Ventricular Cilia and Mitochondrial Proteostasis. Int J Mol Sci. 2026 Apr 14;27(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory