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Rer1 Gene Detail
Summary
  • Symbol
    Rer1
  • Name
    retention in endoplasmic reticulum sorting receptor 1
  • Synonyms
    1110060F11Rik, 5830454N22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915080
    NCBI Gene: 67830
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155158567-155170839 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915080
 protein coding gene Chr4:155158566-155170840 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029207
 protein coding gene Chr4:159363686-159377027 (-)
A/J MGP_AJ_G0029172
 protein coding gene Chr4:152682157-152694274 (-)
AKR/J MGP_AKRJ_G0029120
 protein coding gene Chr4:156837252-156849465 (-)
BALB/cJ MGP_BALBcJ_G0029188
 protein coding gene Chr4:153154978-153167505 (-)
C3H/HeJ MGP_C3HHeJ_G0028909
 protein coding gene Chr4:157372985-157386550 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029637
 protein coding gene Chr4:165059913-165073459 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026883
 protein coding gene Chr4:144979864-144992701 (-)
CAST/EiJ MGP_CASTEiJ_G0028322
 protein coding gene Chr4:154804630-154819801 (-)
CBA/J MGP_CBAJ_G0028871
 protein coding gene Chr4:169998377-170017077 (-)
DBA/2J MGP_DBA2J_G0029020
 protein coding gene Chr4:152702140-152714507 (-)
FVB/NJ MGP_FVBNJ_G0028984
 protein coding gene Chr4:151932369-151945857 (-)
LP/J MGP_LPJ_G0029110
 protein coding gene Chr4:159289919-159301970 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029011
 protein coding gene Chr4:172873684-172886780 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029669
 protein coding gene Chr4:157438132-157450667 (-)
PWK/PhJ MGP_PWKPhJ_G0028042
 protein coding gene Chr4:148825164-148838666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027876
 protein coding gene Chr4:151712991-151726159 (-)
WSB/EiJ MGP_WSBEiJ_G0028402
 protein coding gene Chr4:157599582-157613215 (-)



Homology
more
  • Human Ortholog
    RER1, retention in endoplasmic reticulum sorting receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RER1, retention in endoplasmic reticulum sorting receptor 1
  • Links
    NCBI Gene ID: 11079
    neXtProt AC: NX_O15258
    UniProt: O15258

  • Chr Location
    1p36.32; chr1:2391775-2405442 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trap allele exhibit a slight reduction in the size of neuromuscular junctions and muscle fiber diameter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    50
  • cDNA Data
    148
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029048 Ensembl Gene Model | MGI Sequence Detail 12273 C57BL/6J ±  kb
    transcript ENSMUST00000030914 Ensembl | MGI Sequence Detail 1596 Not Applicable  
    polypeptide ENSMUSP00000030914 Ensembl | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 149

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923352, MGI:2140486
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:266159 Hara T, et al., Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development. PLoS Genet. 2018 Sep;14(9):e1007647
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory