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Arpc5 Gene Detail
Summary
  • Symbol
    Arpc5
  • Name
    actin related protein 2/3 complex, subunit 5
  • Synonyms
    5830443F10Rik, p16-Arc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915021
    NCBI Gene: 67771
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152642293-152651331 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.02 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915021
protein coding gene Chr1:152642293-152651348 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016590
protein coding gene Chr1:157536274-157546830 (+)
A/J MGP_AJ_G0016572
protein coding gene Chr1:151193009-151202062 (+)
AKR/J MGP_AKRJ_G0016537
protein coding gene Chr1:155854552-155864820 (+)
BALB/cJ MGP_BALBcJ_G0016532
protein coding gene Chr1:151765814-151775035 (+)
C3H/HeJ MGP_C3HHeJ_G0016357
protein coding gene Chr1:155971648-155980734 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016993
protein coding gene Chr1:162989879-162999752 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014702
protein coding gene Chr1:143511484-143521105 (+)
CAST/EiJ MGP_CASTEiJ_G0015936
protein coding gene Chr1:155474838-155484032 (+)
CBA/J MGP_CBAJ_G0016331
protein coding gene Chr1:168720937-168732952 (+)
DBA/2J MGP_DBA2J_G0016437
protein coding gene Chr1:150208206-150217279 (+)
FVB/NJ MGP_FVBNJ_G0016435
protein coding gene Chr1:148694759-148703830 (+)
LP/J MGP_LPJ_G0016508
protein coding gene Chr1:158649233-158660559 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016461
protein coding gene Chr1:176370687-176380873 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017029
protein coding gene Chr1:155641600-155651084 (+)
PWK/PhJ MGP_PWKPhJ_G0015722
protein coding gene Chr1:149217208-149231325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015509
protein coding gene Chr1:154449125-154458113 (+)
WSB/EiJ MGP_WSBEiJ_G0015999
protein coding gene Chr1:155705686-155715366 (+)



Homology
more
  • Human Ortholog
    ARPC5, actin related protein 2/3 complex subunit 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARPC5, actin related protein 2/3 complex subunit 5
  • Synonyms
    ARC16, dJ127C7.3, IMD113, p16-Arc
  • Links
    NCBI Gene ID: 10092
    neXtProt AC: NX_O15511
    UniProt: O15511

  • Chr Location
    1q25.3; chr1:183620846-183635783 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human ARPC5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality between E9.5 and E10.5 with incomplete caudal and rostral neuropore closure, absent pharyngeal arches and cardiac outflow tract, impaired somite development, and failure of initiation of embryo turning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67771 NCBI Gene Model | MGI Sequence Detail 9039 C57BL/6J ±  kb
    transcript NM_026369 RefSeq | MGI Sequence Detail 1897 C57BL/6  
    polypeptide Q9CPW4 UniProt | EBI | MGI Sequence Detail 151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004313 actin-related protein 2/3 complex subunit 5
    • PDB
    • InterPro Domains
      IPR006789 Actin-related protein 2/3 complex subunit 5
      IPR036743 Actin-related protein 2/3 complex subunit 5 superfamily
    Molecular
    Reagents
    less
    • All nucleic 395
      cDNA 395

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:334465 Sindram E, et al., ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality. Dis Model Mech. 2023 Jul 1;16(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    05/14/2024
    MGI 6.23
    The Jackson Laboratory