Jagn1 MGI Mouse Gene Detail - MGI:1915017

Symbol

Jagn1
Name

jagunal homolog 1
Synonyms

5830427H10Rik

Feature Type

protein coding gene
IDs

MGI:1915017
NCBI Gene: 67767
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:113419530-113425190 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 52.76 cM
Mapping Data

2 experiments

SNPs within 2kb

57 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915017	protein coding gene	Chr6:113419478-113425190 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031124	protein coding gene	Chr6:115961339-115966995 (+)
A/J	MGP_AJ_G0031093	protein coding gene	Chr6:111519687-111525348 (+)
AKR/J	MGP_AKRJ_G0031024	protein coding gene	Chr6:114513657-114519307 (+)
BALB/cJ	MGP_BALBcJ_G0031104	protein coding gene	Chr6:111465409-111471069 (+)
C3H/HeJ	MGP_C3HHeJ_G0030604	protein coding gene	Chr6:69779094-69784744 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031563	protein coding gene	Chr6:118965854-118971523 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028727	protein coding gene	Chr6:108548116-108552913 (+)
CAST/EiJ	MGP_CASTEiJ_G0030211	protein coding gene	Chr6:114956833-114963729 (+)
CBA/J	MGP_CBAJ_G0030790	protein coding gene	Chr6:123662557-123668207 (+)
DBA/2J	MGP_DBA2J_G0030943	protein coding gene	Chr6:110599066-110604715 (+)
FVB/NJ	MGP_FVBNJ_G0030897	protein coding gene	Chr6:109598450-109604085 (+)
LP/J	MGP_LPJ_G0031023	protein coding gene	Chr6:115998271-116003931 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030931	protein coding gene	Chr6:127926758-127932393 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031590	protein coding gene	Chr6:114527964-114533596 (+)
PWK/PhJ	MGP_PWKPhJ_G0029927	protein coding gene	Chr6:109554831-109560191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029755	protein coding gene	Chr6:113345187-113350406 (+)
WSB/EiJ	MGP_WSBEiJ_G0030295	protein coding gene	Chr6:114902556-114908191 (+)

Human Ortholog

JAGN1, jagunal homolog 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JAGN1, jagunal homolog 1
Synonyms

GL009, SCN6
Links

HGNC:26926

NCBI Gene ID: 84522

neXtProt AC: NX_Q8N5M9

UniProt: Q8N5M9
Chr Location

3p25.3; chr3:9890574-9894349 (+) GRCh38

MGI Vertebrate Homology

Jagn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: JAGN1
Gene Tree

Jagn1

Diseases

1 with human JAGN1 associations

				Human Disease	Mouse Models
				severe congenital neutropenia 6 IDs severe congenital neutropenia 6 DOID:0112134 OMIM:616022 ORDO:423384

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Gene trapped

7
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Jagn1
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available

less

All GO Annotations

16
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

5
cDNA Data

88
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase jagn1

less

All Sequences

49
RefSeq

6
UniProt

2
CCDS

CCDS20419.1, CCDS85121.1

Ensembl

ENSMUSG00000051256 (Evidence)
NCBI Gene

67767

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051256	Ensembl Gene Model \| MGI Sequence Detail	5661	C57BL/6J	± kb
transcript	ENSMUST00000101070	Ensembl \| MGI Sequence Detail	1201	Not Applicable
polypeptide	ENSMUSP00000098631	Ensembl \| MGI Sequence Detail	183	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000009195 protein jagunal homolog 1

(term hierarchy)
InterPro Domains

IPR009787 Protein jagunal

less

All nucleic 88

cDNA 88

Microarray probesets 3

less

MGI:2141660

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Jagn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58212	Chr6:113419532-113419588 (+)	30 bp
Tssr58213	Chr6:113419589-113419596 (+)	63 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23