Stx17 MGI Mouse Gene Detail - MGI:1914977

Symbol

Stx17
Name

syntaxin 17
Synonyms

4833418L03Rik, 6330411F21Rik, 9030425C21Rik

Feature Type

protein coding gene
IDs

MGI:1914977
NCBI Gene: 67727
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:48124915-48186507 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 26.07 cM
Mapping Data

2 experiments

SNPs within 2kb

446 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914977	protein coding gene	Chr4:48124912-48186507 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028271	protein coding gene	Chr4:46542056-46604814 (+)
A/J	MGP_AJ_G0028230	protein coding gene	Chr4:44801870-44861609 (+)
AKR/J	MGP_AKRJ_G0028180	protein coding gene	Chr4:45938531-46002141 (+)
BALB/cJ	MGP_BALBcJ_G0028250	protein coding gene	Chr4:44918469-44977985 (+)
C3H/HeJ	MGP_C3HHeJ_G0027971	protein coding gene	Chr4:46515234-46576709 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028691	protein coding gene	Chr4:48226491-48287888 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026000	protein coding gene	Chr4:42160648-42215785 (+)
CAST/EiJ	MGP_CASTEiJ_G0027410	protein coding gene	Chr4:46104753-46163721 (+)
CBA/J	MGP_CBAJ_G0027937	protein coding gene	Chr4:49783811-49845603 (+)
DBA/2J	MGP_DBA2J_G0028087	protein coding gene	Chr4:44688269-44747242 (+)
FVB/NJ	MGP_FVBNJ_G0028054	protein coding gene	Chr4:43956396-44014949 (+)
LP/J	MGP_LPJ_G0028186	protein coding gene	Chr4:46592869-46655842 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028078	protein coding gene	Chr4:52785859-52846731 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028726	protein coding gene	Chr4:46138480-46194619 (+)
PWK/PhJ	MGP_PWKPhJ_G0027135	protein coding gene	Chr4:44807992-44867073 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026963	protein coding gene	Chr4:45649884-45710593 (+)
WSB/EiJ	MGP_WSBEiJ_G0027488	protein coding gene	Chr4:46072050-46132627 (+)

Human Ortholog

STX17, syntaxin 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX17, syntaxin 17
Links

HGNC:11432

NCBI Gene ID: 55014

neXtProt AC: NX_P56962

UniProt: P56962
Chr Location

9q31.1; chr9:99906654-99974534 (+) GRCh38

MGI Vertebrate Homology

Stx17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STX17
Gene Tree

Stx17

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Loss of cardiac expression alleviates high fat diet induced cardiomyopathy.

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All GO Annotations

54
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

1
cDNA Data

78
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN stx17

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All Sequences

61
RefSeq

10
UniProt

3
CCDS

CCDS18164.1

Ensembl

ENSMUSG00000061455 (Evidence)
NCBI Gene

67727

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061455	Ensembl Gene Model \| MGI Sequence Detail	61593	C57BL/6J	± kb
transcript	ENSMUST00000064765	Ensembl \| MGI Sequence Detail	1531	Not Applicable
polypeptide	ENSMUSP00000068087	Ensembl \| MGI Sequence Detail	301	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015789 syntaxin-17

(term hierarchy)
InterPro Domains

IPR010989 SNARE

IPR045242 Syntaxin

IPR028676 Syntaxin-17, SNARE motif

IPR006012 Syntaxin/epimorphin, conserved site

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 78

cDNA 78

Microarray probesets 9

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MGI:1917982, MGI:1921845, MGI:2140547

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345305 Xu H, et al., Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca(2+) overload in a Parkin-MCUb-dependent manner. Metabolism. 2023 Mar 21;143:155551

TSS for Stx17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37225	Chr4:48124903-48124938 (+)	6 bp
Tssr37226	Chr4:48124944-48124955 (+)	35 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23