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Hypk Gene Detail
Summary
  • Symbol
    Hypk
  • Name
    huntingtin interacting protein K
  • Synonyms
    2310003F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914943
    NCBI Gene: 67693
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121287569-121288921 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.39 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914943
 protein coding gene Chr2:121283771-121289153 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026395
 protein coding gene Chr2:124356159-124361584 (+)
A/J MGP_AJ_G0026356
 protein coding gene Chr2:119271385-119276796 (+)
AKR/J MGP_AKRJ_G0026335
 protein coding gene Chr2:122617241-122622646 (+)
BALB/cJ MGP_BALBcJ_G0026369
 protein coding gene Chr2:119501558-119506863 (+)
C3H/HeJ MGP_C3HHeJ_G0026115
 protein coding gene Chr2:123097642-123103048 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026816
 protein coding gene Chr2:128427259-128432641 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024196
 protein coding gene Chr2:114312175-114317588 (+)
CAST/EiJ MGP_CASTEiJ_G0025577
 protein coding gene Chr2:123426020-123433009 (+)
CBA/J MGP_CBAJ_G0026091
 protein coding gene Chr2:132898354-132903764 (+)
DBA/2J MGP_DBA2J_G0026230
 protein coding gene Chr2:118685307-118690713 (+)
FVB/NJ MGP_FVBNJ_G0026192
 protein coding gene Chr2:117489564-117494979 (+)
LP/J MGP_LPJ_G0026331
 protein coding gene Chr2:124604390-124609799 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026211
 protein coding gene Chr2:137175580-137182308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026871
 protein coding gene Chr2:122727877-122733287 (+)
PWK/PhJ MGP_PWKPhJ_G0025313
 protein coding gene Chr2:118276882-118282393 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025112
 protein coding gene Chr2:121935389-121940806 (+)
WSB/EiJ MGP_WSBEiJ_G0025646
 protein coding gene Chr2:123566253-123572016 (+)



Homology
more
  • Human Ortholog
    HYPK, huntingtin interacting protein K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYPK, huntingtin interacting protein K
  • Synonyms
    C15orf63, HSPC136
  • Links
    NCBI Gene ID: 25764
    neXtProt AC: NX_Q9NX55
    UniProt: Q9NX55

  • Chr Location
    15q15.3; chr15:43796142-43804427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Hypk
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    88
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67693 NCBI Gene Model | MGI Sequence Detail 1353 C57BL/6J ±  kb
transcript NM_026318 RefSeq | MGI Sequence Detail 620 C57BL/6  
polypeptide Q9CR41 UniProt | EBI | MGI Sequence Detail 121 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008854 huntingtin-interacting protein K
    (term hierarchy)
  • InterPro Domains
    IPR038922 Huntingtin-interacting protein K, UBA-like domain
    IPR044034 Nascent polypeptide-associated complex subunit alpha-like, UBA domain
Molecular
Reagents
less
  • All nucleic 88
    cDNA 88

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:230852 Das S, et al., Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease. Exp Cell Res. 2016 May 1;343(2):107-117
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory