Lrrc18 Gene Detail

Summary

• Symbol
  Lrrc18
• Name
  leucine rich repeat containing 18
• Synonyms
  4930442L21Rik, mtLR1

• Feature Type
  protein coding gene
• IDs
  MGI:1914830
  NCBI Gene: 67580
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr14:32713339-32737248 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 19.61 cM, cytoband B
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  707 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914830	protein coding gene	Chr14:32713339-32737257 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021154	protein coding gene	Chr14:26274458-26298317 (+)
A/J	MGP_AJ_G0021102	protein coding gene	Chr14:25264610-25288462 (+)
AKR/J	MGP_AKRJ_G0021079	protein coding gene	Chr14:26412830-26436740 (+)
BALB/cJ	MGP_BALBcJ_G0021106	protein coding gene	Chr14:25440356-25464208 (+)
C3H/HeJ	MGP_C3HHeJ_G0020889	protein coding gene	Chr14:26306074-26329968 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021538	protein coding gene	Chr14:27299861-27324811 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019100	protein coding gene	Chr14:25317659-25341512 (+)
CAST/EiJ	MGP_CASTEiJ_G0020414	protein coding gene	Chr14:26115565-26140383 (+)
CBA/J	MGP_CBAJ_G0020856	protein coding gene	Chr14:28323636-28347474 (+)
DBA/2J	MGP_DBA2J_G0020978	protein coding gene	Chr14:25310885-25335143 (+)
FVB/NJ	MGP_FVBNJ_G0020962	protein coding gene	Chr14:25253775-25277625 (+)
LP/J	MGP_LPJ_G0021047	protein coding gene	Chr14:26589423-26615340 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020988	protein coding gene	Chr14:27509916-27535428 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021571	protein coding gene	Chr14:26220166-26244040 (+)
PWK/PhJ	MGP_PWKPhJ_G0020162	protein coding gene	Chr14:24774949-24799428 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019986	protein coding gene	Chr14:25856127-25879899 (+)
WSB/EiJ	MGP_WSBEiJ_G0020469	protein coding gene	Chr14:26284981-26311466 (+)

Homology

• Human Ortholog
  LRRC18, leucine rich repeat containing 18

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LRRC18, leucine rich repeat containing 18
  
• Synonyms
  UNQ933, UNQ9338, VKGE9338
• Links
  HGNC:23199

  NCBI Gene ID: 474354

  UniProt: Q8N456

  
  
• Chr Location
  chr10:48909480-48939840 (-)  GRCh38

---

• MGI Vertebrate Homology
  Lrrc18 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: LRRC18
• Gene Tree
  Lrrc18
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  13 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  56

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lrrc18

Sequences &
Gene Models

• All Sequences
  55
• RefSeq
  8
• UniProt
  4
• CCDS
  CCDS26924.1, CCDS49440.1

• Ensembl
  ENSMUSG00000041673 (Evidence)
• NCBI Gene
  67580

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000041673	Ensembl Gene Model | MGI Sequence Detail	23910	C57BL/6J
transcript	ENSMUST00000120951	Ensembl | MGI Sequence Detail	1511	Not Applicable
polypeptide	ENSMUSP00000113965	Ensembl | MGI Sequence Detail	309	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000009933 leucine-rich repeat-containing protein 18
  (term hierarchy)
• InterPro Domains
  IPR001611 Leucine-rich repeat
  IPR050216 Leucine-rich repeat domain-containing protein
  IPR032675 Leucine-rich repeat domain superfamily
  IPR003591 Leucine-rich repeat, typical subtype

Molecular
Reagents

• All nucleic 56

  cDNA 56

  
  

  Microarray probesets 7

References

• Summaries
  All 25

  Gene Ontology 2

  Phenotypes 3
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Lrrc18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125003	Chr14:32713336-32713347 (+)	3 bp
Tssr125004	Chr14:32713349-32713360 (+)	16 bp
Tssr125005	Chr14:32713369-32713380 (+)	36 bp
Tssr125006	Chr14:32713387-32713411 (+)	60 bp