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Loxl4 Gene Detail
Summary
  • Symbol
    Loxl4
  • Name
    lysyl oxidase-like 4
  • Synonyms
    4833426I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914823
    NCBI Gene: 67573
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42582421-42601252 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.56 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    739 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914823
 protein coding gene Chr19:42580718-42601326 (-)
129S1/SvImJ ENSMUSG00200026228
 protein coding gene Chr19:39312914-39331620 (-)
A/J ENSMUSG00195010923
 protein coding gene Chr19:39414154-39432865 (-)
AKR/J ENSMUSG00220018745
 protein coding gene Chr19:39229744-39248448 (-)
BALB/cJ ENSMUSG00180031764
 protein coding gene Chr19:39666579-39685288 (-)
C3H/HeJ ENSMUSG00175034868
 protein coding gene Chr19:39192337-39211042 (-)
C57BL/6NJ ENSMUSG00215014244
 protein coding gene Chr19:39272057-39290893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022975
 protein coding gene Chr19:39275371-39294239 (-)
CAST/EiJ ENSTCUG00005014513
 protein coding gene Chr19:38877641-38896594 (-)
CBA/J ENSMUSG00210030045
 protein coding gene Chr19:39274500-39293205 (-)
DBA/2J ENSMUSG00185032528
 protein coding gene Chr19:39790339-39809050 (-)
FVB/NJ ENSMUSG00205006261
 protein coding gene Chr19:38744809-38763515 (-)
JF1/MsJ ENSUMUG00000019318
 protein coding gene Chr19:39961618-39980397 (-)
LP/J ENSMUSG00230024442
 protein coding gene Chr19:40582935-40601641 (-)
NOD/ShiLtJ ENSMUSG00190009784
 protein coding gene Chr19:39140121-39158830 (-)
NZO/HlLtJ ENSMUSG00225043832
 protein coding gene Chr19:44140471-44159203 (-)
PWK/PhJ ENSLUMG00010000840
 protein coding gene Chr19:39130565-39149766 (-)
SPRET/EiJ ENSMSPG00010019821
 protein coding gene Chr19:38860633-38878397 (-)
WSB/EiJ ENSIUOG00005034266
 protein coding gene Chr19:38647745-38666458 (-)



Homology
more
  • Human Ortholog
    LOXL4, lysyl oxidase like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LOXL4, lysyl oxidase like 4
  • Synonyms
    LOXC
  • Links
    NCBI Gene ID: 84171
    UniProt: Q96JB6

  • Chr Location
    10q24.2; chr10:98247690-98268650 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have normal lysyl oxidase enzyme activity in the heart and aorta tissues and show normal development of angiotensin II-induced thoracic and abdominal aortic aneurysms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    21
  • cDNA Data
    15
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025185 Ensembl Gene Model | MGI Sequence Detail 18832 C57BL/6J ±  kb
    transcript ENSMUST00000164786 Ensembl | MGI Sequence Detail 2617 Not Applicable  
    polypeptide ENSMUSP00000125803 Ensembl | MGI Sequence Detail 758 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory