Pabpc6 MGI Mouse Gene Detail - MGI:1914793 - poly(A) binding protein, cytoplasmic 6

Symbol

Pabpc6
Name

poly(A) binding protein, cytoplasmic 6
Synonyms

4932702K14Rik

Feature Type

protein coding gene
IDs

MGI:1914793
NCBI Gene: 67543
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:9885426-9888633 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 7.47 cM
Mapping Data

2 experiments

SNPs within 2kb

152 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914793	protein coding gene	Chr17:9885424-9888646 (-)
129S1/SvImJ	ENSMUSG00200030559	protein coding gene	Chr17:6121282-6124499 (-)
A/J	ENSMUSG00195023292	protein coding gene	Chr17:6328987-6332209 (-)
AKR/J	ENSMUSG00220025142	protein coding gene	Chr17:6394019-6397241 (-)
BALB/cJ	ENSMUSG00180023942	protein coding gene	Chr17:5977032-5980254 (-)
C3H/HeJ	ENSMUSG00175030583	protein coding gene	Chr17:6119340-6122562 (-)
C57BL/6NJ	ENSMUSG00215014730	protein coding gene	Chr17:6128880-6132102 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021058	protein coding gene	Chr17:7235297-7238498 (+)
CAST/EiJ	ENSTCUG00005021103	protein coding gene	Chr17:6357094-6360311 (-)
CBA/J	ENSMUSG00210038126	protein coding gene	Chr17:5786118-5789340 (-)
DBA/2J	ENSMUSG00185021912	protein coding gene	Chr17:6878815-6882037 (-)
FVB/NJ	ENSMUSG00205008057	protein coding gene	Chr17:6189464-6192686 (-)
JF1/MsJ	ENSUMUG00000018184	protein coding gene	Chr17:6460416-6463633 (-)
LP/J	ENSMUSG00230031161	protein coding gene	Chr17:8312573-8315795 (-)
NOD/ShiLtJ	ENSMUSG00190031050	protein coding gene	Chr17:6308599-6311816 (-)
NZO/HlLtJ	ENSMUSG00225047230	protein coding gene	Chr17:10231362-10234584 (-)
PWK/PhJ	ENSLUMG00010018827	protein coding gene	Chr17:6281349-6284555 (-)
SPRET/EiJ	ENSMSPG00010034511	protein coding gene	Chr17:7383355-7386574 (+)
WSB/EiJ	ENSIUOG00005013283	protein coding gene	Chr17:6196014-6199236 (-)

Human Ortholog

PABPC1, poly(A) binding protein cytoplasmic 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PABPC1, poly(A) binding protein cytoplasmic 1
Synonyms

PAB1, PABP, PABP1, PABPC2, PABPL1
Links

HGNC:8554

NCBI Gene ID: 26986

UniProt: P11940
Chr Location

8q22.3; chr8:100685816-100722809 (-) GRCh38

Human Ortholog

PABPC3, poly(A) binding protein cytoplasmic 3
Synonyms

PABP3, PABPL3, tPABP
Links

HGNC:8556

NCBI Gene ID: 5042

UniProt: Q9H361
Chr Location

13q12.13; chr13:25096136-25099254 (+) GRCh38

MGI Vertebrate Homology

Pabpc6 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PABPC1, PABPC3
Gene Tree

Pabpc6

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References

6 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
386 phenotype references

All Mutations and Alleles

14
Endonuclease-mediated

3
Radiation induced

8
Targeted

2
Genomic Mutations

9 involving Pabpc6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygous null mice exhibit no overt abnormalities, with normal male and female fertility.

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

874
Tissues

78
cDNA Data

19
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS49946.1

Ensembl

ENSMUSG00000046173 (Evidence)
NCBI Gene

67543

			Length	Strain/Species	Flank
genomic	67543	NCBI Gene Model \| MGI Sequence Detail	3208	C57BL/6J	± kb
transcript	NM_001163836	RefSeq \| MGI Sequence Detail	3208	C57BL/6
polypeptide	NP_001157308	RefSeq \| MGI Sequence Detail	643	C57BL/6

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UniProt

2 Sequences
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR036053 PABC (PABP) domain

IPR034364 PABP, RNA recognition motif 1

IPR045305 PABP, RNA recognition motif 2

IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryotic-type

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 1

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MGI:2146850

Summaries

All 409

Developmental Gene Expression 3

Diseases 6

Gene Ontology 4

Phenotypes 386
Earliest

J:7073 Washburn LL, et al., Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature. 1983 May 26;303(5915):338-40
Latest

J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815

TSS for Pabpc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5003	Chr17:9888654-9888658 (-)	-23 bp
Tssr146368	Chr17:9888641-9888650 (-)	-13 bp
Tssr146367	Chr17:9888597-9888634 (-)	17 bp
Tssr146366	Chr17:9888578-9888592 (-)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29