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Atg12 Gene Detail
Summary
  • Symbol
    Atg12
  • Name
    autophagy related 12
  • Synonyms
    4931423H11Rik, A330058M13Rik, Apg12l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914776
    NCBI Gene: 67526
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46865484-46874683 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 24.76 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914776
protein coding gene Chr18:46863211-46874683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024412
protein coding gene Chr18:45554569-45563721 (-)
A/J MGP_AJ_G0024379
protein coding gene Chr18:43914690-43923826 (-)
AKR/J MGP_AKRJ_G0024348
protein coding gene Chr18:45112294-45121440 (-)
BALB/cJ MGP_BALBcJ_G0024379
protein coding gene Chr18:44013184-44022323 (-)
C3H/HeJ MGP_C3HHeJ_G0024146
protein coding gene Chr18:45201935-45211090 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024823
protein coding gene Chr18:47151907-47161055 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022258
protein coding gene Chr18:43727538-43736889 (-)
CAST/EiJ MGP_CASTEiJ_G0023620
protein coding gene Chr18:45153563-45162642 (-)
CBA/J MGP_CBAJ_G0024115
protein coding gene Chr18:48432576-48443422 (-)
DBA/2J MGP_DBA2J_G0024245
protein coding gene Chr18:43518898-43528055 (-)
FVB/NJ MGP_FVBNJ_G0024211
protein coding gene Chr18:43084452-43093504 (-)
LP/J MGP_LPJ_G0024329
protein coding gene Chr18:45617496-45626632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024242
protein coding gene Chr18:49800401-49809563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024870
protein coding gene Chr18:45032269-45041421 (-)
PWK/PhJ MGP_PWKPhJ_G0023364
protein coding gene Chr18:43663119-43672272 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023169
protein coding gene Chr18:45173085-45182419 (-)
WSB/EiJ MGP_WSBEiJ_G0023683
protein coding gene Chr18:44931283-44940421 (-)



Homology
more
  • Human Ortholog
    ATG12, autophagy related 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG12, autophagy related 12
  • Synonyms
    APG12, APG12L, FBR93, HAPG12
  • Links
    NCBI Gene ID: 9140
    neXtProt AC: NX_O94817
    UniProt: O94817

  • Chr Location
    5q22.3; chr5:115828200-115841837 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality. Mice homozygous for a conditional allele activated in POMC neurons exhibit increased diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67526 NCBI Gene Model | MGI Sequence Detail 9200 C57BL/6J ±  kb
    transcript NM_026217 RefSeq | MGI Sequence Detail 2492 C57BL/6  
    polypeptide Q9CQY1 UniProt | EBI | MGI Sequence Detail 141 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 133
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443723
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 13
      Gene Ontology 16
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory