Mettl16 MGI Mouse Gene Detail - MGI:1914743 - methyltransferase 16, N6-methyladenosine

Symbol

Mettl16
Name

methyltransferase 16, N6-methyladenosine
Synonyms

2610100D03Rik, 2810013M15Rik, A830095F14Rik, Mett10d

Feature Type

protein coding gene
IDs

MGI:1914743
NCBI Gene: 67493
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:74661658-74716649 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.76 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

1209 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914743	protein coding gene	Chr11:74661656-74719351 (+)
129S1/SvImJ	ENSMUSG00200051166	protein coding gene	Chr11:71785768-71843748 (+)
A/J	ENSMUSG00195037130	protein coding gene	Chr11:71657067-71714781 (+)
AKR/J	ENSMUSG00220046770	protein coding gene	Chr11:71879295-71937286 (+)
BALB/cJ	ENSMUSG00180031624	protein coding gene	Chr11:71852195-71910190 (+)
C3H/HeJ	ENSMUSG00175031647	protein coding gene	Chr11:71822533-71880519 (+)
C57BL/6NJ	ENSMUSG00215038225	protein coding gene	Chr11:71437963-71495671 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016724	protein coding gene	Chr11:69711779-69769705 (+)
CAST/EiJ	ENSTCUG00005053241	protein coding gene	Chr11:71342862-71400486 (+)
CBA/J	ENSMUSG00210038187	protein coding gene	Chr11:71641037-71699015 (+)
DBA/2J	ENSMUSG00185034810	protein coding gene	Chr11:71910995-71968973 (+)
FVB/NJ	ENSMUSG00205041367	protein coding gene	Chr11:71741094-71798801 (+)
JF1/MsJ	ENSUMUG00000034822	protein coding gene	Chr11:72285614-72343616 (+)
LP/J	ENSMUSG00230042150	protein coding gene	Chr11:72941668-72999647 (+)
NOD/ShiLtJ	ENSMUSG00190043503	protein coding gene	Chr11:71957460-72015440 (+)
NZO/HlLtJ	ENSMUSG00225036851	protein coding gene	Chr11:75113511-75171515 (+)
PWK/PhJ	ENSLUMG00010040750	protein coding gene	Chr11:71819101-71876914 (+)
SPRET/EiJ	ENSMSPG00010041761	protein coding gene	Chr11:72223701-72269399 (+)
WSB/EiJ	ENSIUOG00005031603	protein coding gene	Chr11:71810661-71868651 (+)

Human Ortholog

METTL16, methyltransferase 16, RNA N6-adenosine

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

METTL16, methyltransferase 16, RNA N6-adenosine
Synonyms

METT10D
Links

HGNC:28484

NCBI Gene ID: 79066

UniProt: Q86W50
Chr Location

17p13.3; chr17:2405562-2511891 (-) GRCh38

MGI Vertebrate Homology

Mettl16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: METTL16
Protein SuperFamily

Mtase_ZK1128_prd
Gene Tree

Mettl16

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Phenotype Summary

11 phenotypes from 3 alleles in 2 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

92
Chemically induced (other)

1
Endonuclease-mediated

13
Gene trapped

72
Targeted

6
Genomic Mutations

2 involving Mettl16
Incidental Mutations

APF
Find Mice (IMSR)

71 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality around implantation.

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All GO Annotations

59
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

697
Tissues

44
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mettl16

ZFIN mettl16

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All Sequences

76
RefSeq

19
UniProt

5
CCDS

CCDS25036.1

Ensembl

ENSMUSG00000010554 (Evidence)
NCBI Gene

67493

			Length	Strain/Species	Flank
genomic	67493	NCBI Gene Model \| MGI Sequence Detail	54992	C57BL/6J	± kb
transcript	NM_026197	RefSeq \| MGI Sequence Detail	2718	C57BL/6
polypeptide	Q9CQG2	UniProt \| EBI \| MGI Sequence Detail	553	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029627 RNA N(6)-adenosine-methyltransferase METTL16

(term hierarchy)
EC

2.1.1.-, 2.1.1.346, 2.1.1.348
InterPro Domains

IPR017182 Methyltransferase METTL16/PsiM

IPR010286 METTL16/RlmF family

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 17

cDNA 17

Microarray probesets 6

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MGI:1924220, MGI:2144287, MGI:2444613

Summaries

All 63

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 29
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:371434 Liu Y, et al., Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development. Cell Metab. 2025 Aug 12;

TSS for Mettl16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102908	Chr11:74661648-74661702 (+)	17 bp
Tssr102909	Chr11:74661707-74661733 (+)	62 bp
Tssr102910	Chr11:74661734-74661746 (+)	82 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24