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Nvl Gene Detail
Summary
  • Symbol
    Nvl
  • Name
    nuclear VCP-like
  • Synonyms
    1200009I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914709
    NCBI Gene: 67459
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180914703-180971769 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.53 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1941 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914709
 protein coding gene Chr1:180914703-180974557 (-)
129S1/SvImJ ENSMUSG00200021669
 protein coding gene Chr1:178668597-178725672 (-)
A/J ENSMUSG00195038334
 protein coding gene Chr1:178285361-178341812 (-)
AKR/J ENSMUSG00220019183
 protein coding gene Chr1:177519906-177576350 (-)
BALB/cJ ENSMUSG00180033116
 protein coding gene Chr1:178319851-178376888 (-)
C3H/HeJ ENSMUSG00175036312
 protein coding gene Chr1:178495622-178552687 (-)
C57BL/6NJ ENSMUSG00215012296
 protein coding gene Chr1:177720297-177777376 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014989
 protein coding gene Chr1:170970207-171029392 (-)
CAST/EiJ ENSTCUG00005042771
 protein coding gene Chr1:176245255-176303520 (-)
CBA/J ENSMUSG00210018415
 protein coding gene Chr1:178166263-178224469 (-)
DBA/2J ENSMUSG00185034855
 protein coding gene Chr1:182785669-182843870 (-)
FVB/NJ ENSMUSG00205030860
 protein coding gene Chr1:177215996-177273401 (-)
JF1/MsJ ENSUMUG00000014402
 protein coding gene Chr1:181753452-181823222 (-)
LP/J ENSMUSG00230027139
 protein coding gene Chr1:182334084-182391146 (-)
NOD/ShiLtJ ENSMUSG00190027797
 protein coding gene Chr1:178181458-178238514 (-)
NZO/HlLtJ ENSMUSG00225009524
 protein coding gene Chr1:186087068-186143509 (-)
PWK/PhJ ENSLUMG00010015469
 protein coding gene Chr1:177026907-177084024 (-)
SPRET/EiJ ENSMSPG00010029176
 protein coding gene Chr1:180504857-180563590 (-)
WSB/EiJ ENSIUOG00005011412
 protein coding gene Chr1:177394458-177451870 (-)



Homology
more
  • Human Ortholog
    NVL, nuclear VCP like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NVL, nuclear VCP like
  • Synonyms
    NVL2
  • Links
    NCBI Gene ID: 4931
    UniProt: O15381

  • Chr Location
    1q42.11; chr1:224227334-224330189 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    18
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026516 Ensembl Gene Model | MGI Sequence Detail 57067 C57BL/6J ±  kb
transcript ENSMUST00000027797 Ensembl | MGI Sequence Detail 9392 Not Applicable  
polypeptide ENSMUSP00000027797 Ensembl | MGI Sequence Detail 855 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Other 1

    Microarray probesets 7
References
more
  • Summaries
    All 38
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:380429 Lo YH, et al., Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Structure. 2017 May 2;25(5):762-772.e4
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory