About   Help   FAQ
Ergic2 Gene Detail
Summary
  • Symbol
    Ergic2
  • Name
    ERGIC and golgi 2
  • Synonyms
    1200009B18Rik, 4930572C01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914706
    NCBI Gene: 67456
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:148080816-148113886 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 78.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914706
 protein coding gene Chr6:148080577-148113886 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031502
 protein coding gene Chr6:153242660-153278820 (-)
A/J MGP_AJ_G0031477
 protein coding gene Chr6:147167319-147201455 (-)
AKR/J MGP_AKRJ_G0031405
 protein coding gene Chr6:151554984-151591670 (-)
BALB/cJ MGP_BALBcJ_G0031485
 protein coding gene Chr6:146927143-146963638 (-)
C3H/HeJ MGP_C3HHeJ_G0031206
 protein coding gene Chr6:151606096-151640891 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031946
 protein coding gene Chr6:157319991-157353980 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029070
 protein coding gene Chr6:145890437-145923477 (-)
CAST/EiJ MGP_CASTEiJ_G0030575
 protein coding gene Chr6:151257984-151292198 (-)
CBA/J MGP_CBAJ_G0031166
 protein coding gene Chr6:163390877-163424080 (-)
DBA/2J MGP_DBA2J_G0031322
 protein coding gene Chr6:145964488-145997767 (-)
FVB/NJ MGP_FVBNJ_G0031274
 protein coding gene Chr6:144660572-144693926 (-)
LP/J MGP_LPJ_G0031408
 protein coding gene Chr6:153359212-153392491 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031314
 protein coding gene Chr6:167010089-167045406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031979
 protein coding gene Chr6:151393466-151426707 (-)
PWK/PhJ MGP_PWKPhJ_G0030301
 protein coding gene Chr6:144455528-144489045 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030125
 protein coding gene Chr6:149502626-149536058 (-)
WSB/EiJ MGP_WSBEiJ_G0030668
 protein coding gene Chr6:152006002-152039874 (-)



Homology
more
  • Human Ortholog
    ERGIC2, ERGIC and golgi 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERGIC2, ERGIC and golgi 2
  • Synonyms
    cd002, CDA14, Erv41, PTX1
  • Links
    NCBI Gene ID: 51290
    neXtProt AC: NX_Q96RQ1
    UniProt: Q96RQ1

  • Chr Location
    12p11.22; chr12:29337352-29381189 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced point mutation affecting the donor splice site of intron 5 exhibit swelling of the hind feet and tail. Knockout mice exhibit enlarged heart ventricles and decreased heart ventricular contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67456 NCBI Gene Model | MGI Sequence Detail 33071 C57BL/6J ±  kb
    transcript NM_026168 RefSeq | MGI Sequence Detail 3935 C57BL/6  
    polypeptide Q9CR89 UniProt | EBI | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000007175 endoplasmic reticulum-Golgi intermediate compartment protein 2
      (term hierarchy)
    • InterPro Domains
      IPR045888 Endoplasmic reticulum vesicle transporter
      IPR012936 Endoplasmic reticulum vesicle transporter, C-terminal
      IPR039542 Endoplasmic reticulum vesicle transporter, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1889339, MGI:1914993
    References
    more
    • Summaries
      All 38
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
    • Latest
      J:345070 Guan L, et al., ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Traffic. 2022 Mar;23(3):140-157
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory