C1qtnf4 MGI Mouse Gene Detail - MGI:1914695 - C1q and tumor necrosis factor related protein 4

Symbol

C1qtnf4
Name

C1q and tumor necrosis factor related protein 4
Synonyms

0710001E10Rik, 9430004J15Rik, CTRP4

Feature Type

protein coding gene
IDs

MGI:1914695
NCBI Gene: 67445
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:90716204-90720869 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.43 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

7 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914695	protein coding gene	Chr2:90713132-90720870 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026134	protein coding gene	Chr2:92172820-92177485 (+)
A/J	MGP_AJ_G0026095	protein coding gene	Chr2:88492329-88496994 (+)
AKR/J	MGP_AKRJ_G0026076	protein coding gene	Chr2:90941406-90946071 (+)
BALB/cJ	MGP_BALBcJ_G0026104	protein coding gene	Chr2:88654243-88658908 (+)
C3H/HeJ	MGP_C3HHeJ_G0025855	protein coding gene	Chr2:91217114-91221752 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026555	protein coding gene	Chr2:95423711-95428376 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023946	protein coding gene	Chr2:85010792-85015629 (+)
CAST/EiJ	MGP_CASTEiJ_G0025320	protein coding gene	Chr2:91733993-91738660 (+)
CBA/J	MGP_CBAJ_G0025833	protein coding gene	Chr2:98664595-98669260 (+)
DBA/2J	MGP_DBA2J_G0025969	protein coding gene	Chr2:88088958-88093623 (+)
FVB/NJ	MGP_FVBNJ_G0025932	protein coding gene	Chr2:87193180-87197747 (+)
LP/J	MGP_LPJ_G0026073	protein coding gene	Chr2:92381971-92386636 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025958	protein coding gene	Chr2:101719180-101723844 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026609	protein coding gene	Chr2:90991663-90996328 (+)
PWK/PhJ	MGP_PWKPhJ_G0025055	protein coding gene	Chr2:87813120-87817830 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024856	protein coding gene	Chr2:90576860-90581545 (+)
WSB/EiJ	MGP_WSBEiJ_G0025387	protein coding gene	Chr2:91583308-91587974 (+)

Human Ortholog

C1QTNF4, C1q and TNF related 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QTNF4, C1q and TNF related 4
Synonyms

CTRP4, ZACRP4
Links

HGNC:14346

NCBI Gene ID: 114900

neXtProt AC: NX_Q9BXJ3

UniProt: Q9BXJ3
Chr Location

11p11.2; chr11:47589667-47595304 (-) GRCh38

Alliance of Genome Resources

C1qtnf4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: C1QTNF4
Gene Tree

C1qtnf4

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving C1qtnf4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a mutation are viable and show normal fertility. Mice homozygous for a null allele exhibit increased sensitivity to LPS treatment with increased mortality.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

9
cDNA Data

40
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase c1qtnf4

ZFIN c1qtnf4

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C1qtnf4 interacts with 20 markers (Mir34b, Mir34c, Mir96, ...) View All

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All Sequences

43
RefSeq

10
UniProt

2
CCDS

CCDS16417.2

Ensembl

ENSMUSG00000040794 (Evidence)
NCBI Gene

67445

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040794	Ensembl Gene Model \| MGI Sequence Detail	4666	C57BL/6J	± kb
transcript	ENSMUST00000111466	Ensembl \| MGI Sequence Detail	1290	Not Applicable
polypeptide	ENSMUSP00000107091	Ensembl \| MGI Sequence Detail	326	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004886 complement C1q tumor necrosis factor-related protein 4

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR008983 Tumour necrosis factor-like domain superfamily

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All nucleic 41

cDNA 41

Microarray probesets 2

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MGI:1924490

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:318011 Sarver DC, et al., CTRP4 ablation impairs associative learning and memory. FASEB J. 2021 Nov;35(11):e21910

TSS for C1qtnf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18781	Chr2:90715765-90715770 (+)	-436 bp
Tssr18782	Chr2:90715794-90715803 (+)	-405 bp
Tssr18783	Chr2:90715819-90715845 (+)	-372 bp
Tssr18784	Chr2:90715847-90715867 (+)	-347 bp
Tssr18785	Chr2:90715871-90715905 (+)	-316 bp
Tssr18786	Chr2:90716108-90716115 (+)	-92 bp
Tssr18787	Chr2:90716132-90716193 (+)	-41 bp
Tssr18788	Chr2:90716205-90716216 (+)	7 bp
Tssr18789	Chr2:90716220-90716246 (+)	29 bp
Tssr18790	Chr2:90716248-90716258 (+)	49 bp
Tssr18791	Chr2:90716268-90716283 (+)	72 bp
Tssr18792	Chr2:90720237-90720248 (+)	4,039 bp
Tssr18793	Chr2:90720250-90720298 (+)	4,070 bp
Tssr18794	Chr2:90720306-90720338 (+)	4,118 bp
Tssr18795	Chr2:90720339-90720355 (+)	4,143 bp
Tssr18796	Chr2:90720594-90720607 (+)	4,397 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/28/2023 MGI 6.22