About   Help   FAQ
Bag4 Gene Detail
Summary
  • Symbol
    Bag4
  • Name
    BCL2-associated athanogene 4
  • Synonyms
    2410112I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914634
    NCBI Gene: 67384
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26254566-26275237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.17 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914634
 protein coding gene Chr8:26254566-26275315 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033487
 protein coding gene Chr8:23832421-23854819 (-)
A/J MGP_AJ_G0033467
 protein coding gene Chr8:22969359-22990050 (-)
AKR/J MGP_AKRJ_G0033392
 protein coding gene Chr8:23729376-23750038 (-)
BALB/cJ MGP_BALBcJ_G0033463
 protein coding gene Chr8:23115642-23136316 (-)
C3H/HeJ MGP_C3HHeJ_G0033177
 protein coding gene Chr8:23940341-23961000 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033979
 protein coding gene Chr8:24801195-24821844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030929
 protein coding gene Chr8:20234026-20254940 (-)
CAST/EiJ MGP_CASTEiJ_G0032503
 protein coding gene Chr8:23389553-23410882 (-)
CBA/J MGP_CBAJ_G0033152
 protein coding gene Chr8:25770542-25791221 (-)
DBA/2J MGP_DBA2J_G0033307
 protein coding gene Chr8:22939384-22960042 (-)
FVB/NJ MGP_FVBNJ_G0033251
 protein coding gene Chr8:22745644-22766312 (-)
LP/J MGP_LPJ_G0033396
 protein coding gene Chr8:23814225-23834896 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033294
 protein coding gene Chr8:25228326-25248996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033998
 protein coding gene Chr8:23663281-23683952 (-)
PWK/PhJ MGP_PWKPhJ_G0032214
 protein coding gene Chr8:22580169-22600563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032048
 protein coding gene Chr8:23035584-23059051 (-)
WSB/EiJ MGP_WSBEiJ_G0032619
 protein coding gene Chr8:23882176-23902829 (-)



Homology
more
  • Human Ortholog
    BAG4, BAG cochaperone 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAG4, BAG cochaperone 4
  • Synonyms
    BAG-4, SODD
  • Links
    NCBI Gene ID: 9530
    neXtProt AC: NX_O95429
    UniProt: O95429

  • Chr Location
    8p11.23; chr8:38176533-38213301 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals may show enhanced cytokine response and increased IL-6 production following TNF challenge. Studies on two different alleles of this gene are not in agreement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67384 NCBI Gene Model | MGI Sequence Detail 20672 C57BL/6J ±  kb
    transcript NM_026121 RefSeq | MGI Sequence Detail 4798 Not Specified  
    polypeptide Q8CI61 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 5
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:176630 Rahman P, et al., Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton. J Biol Chem. 2011 Aug 26;286(34):29758-70
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory