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Dedd2 Gene Detail
Summary
  • Symbol
    Dedd2
  • Name
    death effector domain-containing DNA binding protein 2
  • Synonyms
    2410050E11Rik, FLAME-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914629
    NCBI Gene: 67379
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24899337-24920035 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    642 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914629
 protein coding gene Chr7:24899337-24920040 (-)
129S1/SvImJ ENSMUSG00200040066
 protein coding gene Chr7:14903265-14924824 (-)
A/J ENSMUSG00195048549
 protein coding gene Chr7:17340253-17361546 (-)
AKR/J ENSMUSG00220051965
 protein coding gene Chr7:27029036-27050326 (+)
BALB/cJ ENSMUSG00180052043
 protein coding gene Chr7:15412223-15433515 (-)
C3H/HeJ ENSMUSG00175041432
 protein coding gene Chr7:16456356-16477645 (-)
C57BL/6NJ ENSMUSG00215054731
 protein coding gene Chr7:14816189-14837474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029358
 protein coding gene Chr7:24466991-24487378 (-)
CAST/EiJ ENSTCUG00005048443
 protein coding gene Chr7:16511263-16532360 (-)
CBA/J ENSMUSG00210053068
 protein coding gene Chr7:15642075-15663364 (-)
DBA/2J ENSMUSG00185053984
 protein coding gene Chr7:18855829-18877118 (-)
FVB/NJ ENSMUSG00205023688
 protein coding gene Chr7:15652665-15673957 (-)
JF1/MsJ ENSUMUG00000054961
 protein coding gene Chr7:23151424-23172981 (-)
LP/J ENSMUSG00230052210
 protein coding gene Chr7:24129427-24150986 (-)
NOD/ShiLtJ ENSMUSG00190030223
 protein coding gene Chr7:15122980-15144262 (-)
NZO/HlLtJ ENSMUSG00225026763
 protein coding gene Chr7:22797832-22819121 (-)
PWK/PhJ ENSLUMG00010044140
 protein coding gene Chr7:15085323-15106832 (-)
SPRET/EiJ ENSMSPG00010050221
 protein coding gene Chr7:14753328-14772854 (-)
WSB/EiJ ENSIUOG00005050637
 protein coding gene Chr7:9617901-9639314 (-)



Homology
more
  • Human Ortholog
    DEDD2, death effector domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEDD2, death effector domain containing 2
  • Synonyms
    FLAME-3, FLAME3
  • Links
    NCBI Gene ID: 162989
    UniProt: Q8WXF8

  • Chr Location
    19q13.2; chr19:42198593-42220140 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    53
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67379 NCBI Gene Model | MGI Sequence Detail 20699 C57BL/6J ±  kb
transcript NM_207677 RefSeq | MGI Sequence Detail 1828 FVB/N  
polypeptide Q8QZV0 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory