About   Help   FAQ
Herc4 Gene Detail
Summary
  • Symbol
    Herc4
  • Name
    hect domain and RLD 4
  • Synonyms
    1700056O17Rik, 4921531D01Rik, 9530080M15Rik, mKIAA1593
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914595
    NCBI Gene: 67345
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:63079589-63153657 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.56 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914595
protein coding gene Chr10:63079122-63153660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017314
protein coding gene Chr10:62755135-62837993 (+)
A/J MGP_AJ_G0017292
protein coding gene Chr10:60792486-60868134 (+)
AKR/J MGP_AKRJ_G0017252
protein coding gene Chr10:62401247-62482346 (+)
BALB/cJ MGP_BALBcJ_G0017252
protein coding gene Chr10:60905543-60979370 (+)
C3H/HeJ MGP_C3HHeJ_G0017075
protein coding gene Chr10:62319778-62401782 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017710
protein coding gene Chr10:65007759-65091388 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015400
protein coding gene Chr10:57723201-57797493 (+)
CAST/EiJ MGP_CASTEiJ_G0016646
protein coding gene Chr10:62382584-62472335 (+)
CBA/J MGP_CBAJ_G0017047
protein coding gene Chr10:67481104-67572546 (+)
DBA/2J MGP_DBA2J_G0017152
protein coding gene Chr10:60063099-60143098 (+)
FVB/NJ MGP_FVBNJ_G0017146
protein coding gene Chr10:59337050-59412606 (+)
LP/J MGP_LPJ_G0017226
protein coding gene Chr10:63160193-63241076 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017174
protein coding gene Chr10:69623607-69711177 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017748
protein coding gene Chr10:62241655-62318671 (+)
PWK/PhJ MGP_PWKPhJ_G0016429
protein coding gene Chr10:59950372-60026424 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016211
protein coding gene Chr10:61584221-61663255 (+)
WSB/EiJ MGP_WSBEiJ_G0016710
protein coding gene Chr10:62197006-62283985 (+)



Homology
more
  • Human Ortholog
    HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • Links
    NCBI Gene ID: 26091
    neXtProt AC: NX_Q5GLZ8
    UniProt: Q5GLZ8

  • Chr Location
    10q21.3; chr10:67921899-68075301 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele display reduced male fertility associated with a high percentage of angulated sperm tails and impaired sperm motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020064 Ensembl Gene Model | MGI Sequence Detail 74069 C57BL/6J ±  kb
    transcript ENSMUST00000219577 Ensembl | MGI Sequence Detail 3914 Not Applicable  
    polypeptide ENSMUSP00000151886 Ensembl | MGI Sequence Detail 1057 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000032543 probable E3 ubiquitin-protein ligase HERC4
    • EC
    • InterPro Domains
      IPR051625 Diverse Signaling and Regulatory Domain-Containing Protein
      IPR000569 HECT domain
      IPR035983 HECT, E3 ligase catalytic domain
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR051210 Ubiquitin ligases and GEF domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924839, MGI:1925766
    References
    more
    • Summaries
      All 47
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory