Adissp MGI Mouse Gene Detail - MGI:1914576 - adipose secreted signaling protein

Symbol

Adissp
Name

adipose secreted signaling protein
Synonyms

1700037H04Rik

Feature Type

protein coding gene
IDs

MGI:1914576
NCBI Gene: 67326
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:130988244-131002001 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.28 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914576	protein coding gene	Chr2:130988235-131002001 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026523	protein coding gene	Chr2:134657452-134672851 (-)
A/J	MGP_AJ_G0026487	protein coding gene	Chr2:129192827-129206568 (-)
AKR/J	MGP_AKRJ_G0026462	protein coding gene	Chr2:132926111-132939874 (-)
BALB/cJ	MGP_BALBcJ_G0026499	protein coding gene	Chr2:129578845-129592936 (-)
C3H/HeJ	MGP_C3HHeJ_G0026242	protein coding gene	Chr2:133359837-133374141 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026944	protein coding gene	Chr2:138794904-138809296 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024321	protein coding gene	Chr2:123936988-123950666 (-)
CAST/EiJ	MGP_CASTEiJ_G0025703	protein coding gene	Chr2:133643461-133657211 (-)
CBA/J	MGP_CBAJ_G0026222	protein coding gene	Chr2:143961491-143978541 (-)
DBA/2J	MGP_DBA2J_G0026356	protein coding gene	Chr2:128583048-128597041 (-)
FVB/NJ	MGP_FVBNJ_G0026320	protein coding gene	Chr2:127211665-127226512 (-)
LP/J	MGP_LPJ_G0026461	protein coding gene	Chr2:134887632-134902229 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026340	protein coding gene	Chr2:147778571-147794320 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026999	protein coding gene	Chr2:132881976-132895765 (-)
PWK/PhJ	MGP_PWKPhJ_G0025439	protein coding gene	Chr2:128152404-128166428 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025241	protein coding gene	Chr2:132033399-132047187 (-)
WSB/EiJ	MGP_WSBEiJ_G0025777	protein coding gene	Chr2:133804162-133817879 (-)

Human Ortholog

ADISSP, adipose secreted signaling protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADISSP, adipose secreted signaling protein
Synonyms

C20orf27
Links

HGNC:15873

NCBI Gene ID: 54976

neXtProt AC: NX_Q9GZN8

UniProt: Q9GZN8
Chr Location

20p13; chr20:3753508-3768388 (-) GRCh38

Alliance of Genome Resources

Adissp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADISSP
Gene Tree

Adissp

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Gene trapped

24
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Adissp
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

28
cDNA Data

74
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Adissp interacts with 96 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

60
RefSeq

12
UniProt

5
CCDS

CCDS16756.1, CCDS79849.1

Ensembl

ENSMUSG00000027327 (Evidence)
NCBI Gene

67326

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027327	Ensembl Gene Model \| MGI Sequence Detail	13758	C57BL/6J	± kb
transcript	ENSMUST00000028800	Ensembl \| MGI Sequence Detail	832	Not Applicable
polypeptide	ENSMUSP00000028800	Ensembl \| MGI Sequence Detail	177	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000060065 UPF0687 protein C20orf27

(term hierarchy)
InterPro Domains

IPR026794 Adipose-secreted signaling protein

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All nucleic 74

cDNA 74

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:332979 Chen Q, et al., A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Nat Commun. 2022 Dec 10;13(1):7633

TSS for Adissp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26381	Chr2:131001926-131001971 (-)	52 bp
Tssr26380	Chr2:131001902-131001925 (-)	87 bp
Tssr26379	Chr2:131000465-131000475 (-)	1,531 bp
Tssr26378	Chr2:131000436-131000445 (-)	1,560 bp
Tssr26377	Chr2:130990387-130990400 (-)	11,607 bp
Tssr26376	Chr2:130990326-130990369 (-)	11,653 bp
Tssr26375	Chr2:130988736-130988750 (-)	13,258 bp
Tssr26374	Chr2:130988686-130988710 (-)	13,303 bp
Tssr26373	Chr2:130988491-130988500 (-)	13,505 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/28/2023 MGI 6.22